Fields »
ABOUT
HELP
BLOG
CNGA3

GENERAL INFORMATION

Gene name

 CNGA3

Gene description

 Cyclic nucleotide gated channel alpha 3

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (glioma)
HPA (cell line):Cell line enriched (U-87 MG)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CNGA3 (HGNC Symbol)

Synonyms

 ACHM2, CCNC1, CCNCa, CNCG3, CNG3

Description

 Cyclic nucleotide gated channel alpha 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cyclic nucleotide-gated cation channel protein family which is required for normal vision and olfactory signal transduction. Mutations in this gene are associated with achromatopsia (rod monochromacy) and color blindness. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q11.2

Chromosome location (bp)

 98346155 - 98398601

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144191 (version 83.38)

Entrez gene

 1261

UniProt

 Q16281 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16281

Antibodypedia

 CNGA3 antibodies

PROTEIN BROWSER
CNGA3-001
CNGA3-002
CNGA3-003
CNGA3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNGA3-001
ENSP00000272602
ENST00000272602
Q16281 [Direct mapping]
Cyclic nucleotide-gated cation channel alpha-3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0030553 [cGMP binding]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 694 aa
78.8 kDa 		No 4
CNGA3-002
ENSP00000410070
ENST00000436404
Q16281 [Direct mapping]
Cyclic nucleotide-gated cation channel alpha-3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0030553 [cGMP binding]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 676 aa
76.9 kDa 		No 4
CNGA3-003
ENSP00000386761
ENST00000409937
Q16281 [Direct mapping]
Cyclic nucleotide-gated cation channel alpha-3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0005216 [ion channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0030553 [cGMP binding]
GO:0042391 [regulation of membrane potential]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 698 aa
79.1 kDa 		No 4
CNGA3-201
ENSP00000377140
ENST00000393504
Q16281 [Direct mapping]
Cyclic nucleotide-gated cation channel alpha-3
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Cyclic Nucleotide-Regulated Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005221 [intracellular cyclic nucleotide activated cation channel activity]
GO:0005222 [intracellular cAMP activated cation channel activity]
GO:0005223 [intracellular cGMP activated cation channel activity]
GO:0005249 [voltage-gated potassium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006812 [cation transport]
GO:0007165 [signal transduction]
GO:0007601 [visual perception]
GO:0008022 [protein C-terminus binding]
GO:0015276 [ligand-gated ion channel activity]
GO:0016020 [membrane]
GO:0030425 [dendrite]
GO:0030553 [cGMP binding]
GO:0031960 [response to corticosteroid]
GO:0032026 [response to magnesium ion]
GO:0034220 [ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0042622 [photoreceptor outer segment membrane]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0046549 [retinal cone cell development]
GO:0051591 [response to cAMP]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
GO:1902495 [transmembrane transporter complex]
Show all
 694 aa
78.8 kDa 		No 4

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.