Cell atlas - AFF3 - The Human Protein Atlas

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AFF3

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	AFF3
Gene description	AF4/FMR2 family, member 3
Protein class	Cancer-related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (U-698, Daudi)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA053379
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-698, Daudi) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA053379	A-431	Nucleoplasm
	HPA053379	A-431	Cytosol
	HPA053379	U-2 OS	Nucleoplasm
	HPA053379	U-251 MG	Nucleoplasm
			Nuclear bodies
			Cytosol

GENE INFORMATION
Gene name	AFF3 (HGNC Symbol)
Synonyms	LAF4, MLLT2-like
Description	AF4/FMR2 family, member 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q11.2
Chromosome location (bp)	99545419 - 100142739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144218 (version 83.38)
Entrez gene	3899
UniProt	P51826 (UniProt - Evidence at protein level)
neXtProt	NX_P51826
Antibodypedia	AFF3 antibodies

PROTEIN BROWSER

AFF3-001	AFF3-002	AFF3-003	AFF3-005	AFF3-006	AFF3-007	AFF3-008	AFF3-009	AFF3-010	AFF3-014	AFF3-015	AFF3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AFF3-001 ENSP00000387207 ENST00000409236	P51826 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003690 [double-stranded DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0034612 [response to tumor necrosis factor] GO:0035116 [embryonic hindlimb morphogenesis] Show all	1226 aa 133.5 kDa	No	0
AFF3-002 ENSP00000386834 ENST00000409579	P51826 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003690 [double-stranded DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0034612 [response to tumor necrosis factor] GO:0035116 [embryonic hindlimb morphogenesis] Show all	1251 aa 136.4 kDa	No	0
AFF3-003 ENSP00000396582 ENST00000423966	C9JC67 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17.5 kDa	No	0
AFF3-005 ENSP00000395068 ENST00000416492	C9JMS1 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.6 kDa	No	0
AFF3-006 ENSP00000411383 ENST00000424600	C9J847 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13.3 kDa	No	0
AFF3-007 ENSP00000399795 ENST00000441400	C9JZ66 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.8 kDa	No	0
AFF3-008 ENSP00000393732 ENST00000440445	C9JUC4 [Direct mapping] AF4/FMR2 family member 3 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		155 aa 17.5 kDa	No	0
AFF3-009 ENSP00000407448 ENST00000415384	C9JUY1 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		183 aa 19.9 kDa	No	0
AFF3-010 ENSP00000416131 ENST00000427118	C9JIB1 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		17 aa 2 kDa	No	0
AFF3-014 ENSP00000406484 ENST00000432037	C9J622 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		161 aa 18.2 kDa	No	0
AFF3-015 ENSP00000416685 ENST00000445815	H7C4C2 [Direct mapping] AF4/FMR2 family member 3 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		185 aa 20.7 kDa	No	0
AFF3-201 ENSP00000317421 ENST00000317233	P51826 [Direct mapping] AF4/FMR2 family member 3 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003690 [double-stranded DNA binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0034612 [response to tumor necrosis factor] GO:0035116 [embryonic hindlimb morphogenesis] Show all	1226 aa 133.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.