Expression of TMEFF2 in cancer - Summary - The Human Protein Atlas

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TMEFF2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEFF2
Gene description	Transmembrane protein with EGF-like and two follistatin-like domains 2
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Group enriched (AF22, LHCN-M2)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, prostate, seminal vesicle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA015587
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA015587

GENE INFORMATION
Gene name	TMEFF2 (HGNC Symbol)
Synonyms	CT120.2, HPP1, TENB2, TPEF, TR
Description	Transmembrane protein with EGF-like and two follistatin-like domains 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tomoregulin family of transmembrane proteins. This protein has been shown to function as both an oncogene and a tumor suppressor depending on the cellular context and may regulate prostate cancer cell invasion. Multiple soluble forms of this protein have been identified that arise from both an alternative splice variant and ectodomain shedding. Additionally, this gene has been found to be hypermethylated in multiple cancer types. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Chromosome	2
Cytoband	q32.3
Chromosome location (bp)	191949043 - 192195709
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144339 (version 83.38)
Entrez gene	23671
UniProt	Q9UIK5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UIK5
Antibodypedia	TMEFF2 antibodies

PROTEIN BROWSER

TMEFF2-001	TMEFF2-002	TMEFF2-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEFF2-001 ENSP00000272771 ENST00000272771	Q9UIK5 [Direct mapping] Tomoregulin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0016021 [integral component of membrane] Show all	374 aa 41.4 kDa	No	1
TMEFF2-002 ENSP00000376128 ENST00000392314	Q9UIK5 [Direct mapping] Tomoregulin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0016021 [integral component of membrane] Show all	346 aa 38.1 kDa	No	1
TMEFF2-003 ENSP00000386871 ENST00000409056	Q9UIK5 [Direct mapping] Tomoregulin-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0016021 [integral component of membrane] Show all	175 aa 19.5 kDa	No	2

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.