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DLX1

GENERAL INFORMATION

Gene name

 DLX1

Gene description

 Distal-less homeobox 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adrenal gland, cerebral cortex)
GTEx:Tissue enhanced (cerebral cortex, hypothalamus)
FANTOM5:Tissue enhanced (brain, hippocampus)

Protein evidence

 Evidence at transcript level

Protein expression

 Expression in a selected set of tissues, with distinct expression in nerve fibers in brain.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded. Sub cellular location is contradicted by external data.

Reliability score

 Approved based on 1 antibody.
HPA045884
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adrenal gland, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, hypothalamus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, hippocampus)

GENE INFORMATION

Gene name

 DLX1

Synonyms

Description

 Distal-less homeobox 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q31.1

Chromosome location (bp)

 172084740 - 172089677

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000144355 (version 83.38)

Entrez gene

 1745

UniProt

 P56177 (UniProt - Evidence at transcript level)

neXtProt

 NX_P56177

Antibodypedia

 DLX1 antibodies

PROTEIN BROWSER
DLX1-001
DLX1-002
DLX1-004
DLX1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DLX1-001
ENSP00000354478
ENST00000361725
P56177 [Direct mapping]
Homeobox protein DLX-1
X5D2F9 [Target identity:100%; Query identity:100%]
Distal-less homeobox 1 isoform A
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009954 [proximal/distal pattern formation]
GO:0021544 [subpallium development]
GO:0021766 [hippocampus development]
GO:0021879 [forebrain neuron differentiation]
GO:0021882 [regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment]
GO:0021892 [cerebral cortex GABAergic interneuron differentiation]
GO:0021893 [cerebral cortex GABAergic interneuron fate commitment]
GO:0030154 [cell differentiation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0043565 [sequence-specific DNA binding]
GO:0045746 [negative regulation of Notch signaling pathway]
GO:0048706 [embryonic skeletal system development]
GO:0048715 [negative regulation of oligodendrocyte differentiation]
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 255 aa
27.3 kDa 		No 0
DLX1-002
ENSP00000341786
ENST00000341900
P56177 [Direct mapping]
Homeobox protein DLX-1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
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GO:0005634 [nucleus]
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 129 aa
13.5 kDa 		No 0
DLX1-004
ENSP00000448827
ENST00000469444
F8VXJ2 [Direct mapping]
Homeobox protein DLX-1
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043565 [sequence-specific DNA binding]
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 187 aa
20.5 kDa 		No 0
DLX1-006
ENSP00000354865
ENST00000361609
J3KP55 [Direct mapping]
Homeobox protein DLX-1
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Predicted intracellular proteins
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GO:0003677 [DNA binding]
GO:0005634 [nucleus]
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 171 aa
18.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.