Expression of PHOSPHO2 in cancer - Summary - The Human Protein Atlas

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PHOSPHO2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PHOSPHO2
Gene description	Phosphatase, orphan 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA034726 , HPA034727
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034726	HPA034727

GENE INFORMATION
Gene name	PHOSPHO2 (HGNC Symbol)
Synonyms	MGC22679
Description	Phosphatase, orphan 2 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	169694454 - 169701708
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144362 (version 83.38)
Entrez gene	493911
UniProt	Q8TCD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TCD6
Antibodypedia	PHOSPHO2 antibodies

PROTEIN BROWSER

PHOSPHO2-001	PHOSPHO2-002	PHOSPHO2-003	PHOSPHO2-005	PHOSPHO2-201	PHOSPHO2-202	PHOSPHO2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PHOSPHO2-001 ENSP00000352782 ENST00000359744	Q8TCD6 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0033883 [pyridoxal phosphatase activity] GO:0046872 [metal ion binding] Show all	241 aa 27.8 kDa	No	0
PHOSPHO2-002 ENSP00000411844 ENST00000438710	C9J4G2 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	136 aa 15.8 kDa	No	0
PHOSPHO2-003 ENSP00000416790 ENST00000449906	C9JD35 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	49 aa 5.8 kDa	No	0
PHOSPHO2-005 ENSP00000393983 ENST00000438838	C9JZQ7 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Predicted intracellular proteins Show all	GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	56 aa 6.7 kDa	No	0
PHOSPHO2-201 ENSP00000481680 ENST00000616481	Q8TCD6 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0033883 [pyridoxal phosphatase activity] GO:0046872 [metal ion binding] Show all	241 aa 27.8 kDa	No	0
PHOSPHO2-202 ENSP00000481046 ENST00000616524	Q8TCD6 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0033883 [pyridoxal phosphatase activity] GO:0046872 [metal ion binding] Show all	241 aa 27.8 kDa	No	0
PHOSPHO2-203 ENSP00000481857 ENST00000617738	Q8TCD6 [Direct mapping] Pyridoxal phosphate phosphatase PHOSPHO2 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008152 [metabolic process] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0033883 [pyridoxal phosphatase activity] GO:0046872 [metal ion binding] Show all	241 aa 27.8 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.