Expression of GULP1 in cancer - Summary - The Human Protein Atlas

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GULP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GULP1
Gene description	GULP, engulfment adaptor PTB domain containing 1
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (AF22, WM-115)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA020587
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and stomach cancer (unfavourable).
Renal cancer p<0.001 Stomach cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA020587

GENE INFORMATION
Gene name	GULP1 (HGNC Symbol)
Synonyms	CED-6, CED6, GULP
Description	GULP, engulfment adaptor PTB domain containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	2
Cytoband
Chromosome location (bp)	188291669 - 188595931
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144366 (version 83.38)
Entrez gene	51454
UniProt	Q9UBP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBP9
Antibodypedia	GULP1 antibodies

PROTEIN BROWSER

GULP1-001	GULP1-002	GULP1-003	GULP1-004	GULP1-005	GULP1-006	GULP1-007	GULP1-008	GULP1-010	GULP1-015	GULP1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GULP1-001 ENSP00000352047 ENST00000359135	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	304 aa 34.5 kDa	No	0
GULP1-002 ENSP00000386867 ENST00000409609	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	304 aa 34.5 kDa	No	0
GULP1-003 ENSP00000386289 ENST00000409580	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	304 aa 34.5 kDa	No	0
GULP1-004 ENSP00000387144 ENST00000409843	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	291 aa 33.3 kDa	No	0
GULP1-005 ENSP00000386732 ENST00000409830	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	304 aa 34.5 kDa	No	0
GULP1-006 ENSP00000387013 ENST00000410051	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	167 aa 19.4 kDa	No	1
GULP1-007 ENSP00000386402 ENST00000409637	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	167 aa 19.4 kDa	No	1
GULP1-008 ENSP00000386809 ENST00000409927	B8ZZL1 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	68 aa 7.9 kDa	No	0
GULP1-010 ENSP00000387171 ENST00000409805	Q9UBP9 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006911 [phagocytosis, engulfment] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] Show all	201 aa 22.6 kDa	No	0
GULP1-015 ENSP00000391712 ENST00000433052	H7BZV7 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		189 aa 20.5 kDa	No	0
GULP1-018 ENSP00000407131 ENST00000451191	H0Y6R1 [Direct mapping] PTB domain-containing engulfment adapter protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.6 kDa	No	0

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