Expression of PTH2R in cancer - Summary - The Human Protein Atlas

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PTH2R

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PTH2R
Gene description	Parathyroid hormone 2 receptor
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (renal cancer)
HPA (cell line):	Group enriched (EFO-21, HEL, HL-60, SH-SY5Y)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues, most abundant in pancreas and kidney.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. GTEx and external characterization data supports the antibody staining in pancreas and kidney.
Reliability score	Approved based on 1 antibody. HPA010655
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010655

GENE INFORMATION
Gene name	PTH2R (HGNC Symbol)
Synonyms	PTHR2
Description	Parathyroid hormone 2 receptor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	208359714 - 208854503
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144407 (version 83.38)
Entrez gene	5746
UniProt	P49190 (UniProt - Evidence at protein level)
neXtProt	NX_P49190
Antibodypedia	PTH2R antibodies

PROTEIN BROWSER

PTH2R-001	PTH2R-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTH2R-001 ENSP00000272847 ENST00000272847	P49190 [Direct mapping] Parathyroid hormone 2 receptor Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Biotech drugs Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004991 [parathyroid hormone receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	550 aa 62.2 kDa	Yes	7
PTH2R-002 ENSP00000482485 ENST00000617735	B4DFN8 [Direct mapping] Parathyroid hormone 2 receptor; cDNA FLJ60238, highly similar to Parathyroid hormone receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	439 aa 50 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.