Cell atlas - SPAG16 - The Human Protein Atlas

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SPAG16

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	SPAG16
Gene description	Sperm associated antigen 16
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA037542
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA037542	A-431	Plasma membrane
	HPA037542	A-431	Cytosol
	HPA037542	U-2 OS	Cytosol
	HPA037542	U-251 MG	No staining

GENE INFORMATION
Gene name	SPAG16 (HGNC Symbol)
Synonyms	DKFZp666P1710, FLJ22724, PF20, WDR29
Description	Sperm associated antigen 16 (HGNC Symbol)
Entrez gene summary	Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]
Chromosome	2
Cytoband	q34
Chromosome location (bp)	213284379 - 214410501
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144451 (version 83.38)
Entrez gene	79582
UniProt	Q8N0X2 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N0X2
Antibodypedia	SPAG16 antibodies

PROTEIN BROWSER

SPAG16-001	SPAG16-002	SPAG16-004	SPAG16-006	SPAG16-007	SPAG16-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPAG16-001 ENSP00000332592 ENST00000331683	Q8N0X2 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005856 [cytoskeleton] GO:0005930 [axoneme] GO:0007288 [sperm axoneme assembly] GO:0019901 [protein kinase binding] GO:0031514 [motile cilium] GO:0035082 [axoneme assembly] GO:0042384 [cilium assembly] GO:0051012 [microtubule sliding] GO:0060294 [cilium movement involved in cell motility] GO:0097231 [cell motility in response to calcium ion] GO:1990716 [axonemal central apparatus] Show all	631 aa 70.8 kDa	No	0
SPAG16-002 ENSP00000415079 ENST00000432529	Q8N0X2 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Show all	GO:0005856 [cytoskeleton] GO:0005930 [axoneme] GO:0031514 [motile cilium] GO:0035082 [axoneme assembly] GO:0042384 [cilium assembly] Show all	183 aa 20.6 kDa	No	0
SPAG16-004 ENSP00000390494 ENST00000413312	A0A0C4DG20 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Show all		251 aa 29.1 kDa	No	0
SPAG16-006 ENSP00000400847 ENST00000447990	E7EWV3 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Show all		374 aa 42.8 kDa	No	0
SPAG16-007 ENSP00000416600 ENST00000451561	H0Y811 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	255 aa 28.2 kDa	No	0
SPAG16-201 ENSP00000272898 ENST00000272898	A0A0A0MQX0 [Direct mapping] Sperm-associated antigen 16 protein Show all	Predicted intracellular proteins Show all		318 aa 36.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.