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ABCA12

GENERAL INFORMATION

Gene name

 ABCA12

Gene description

 ATP-binding cassette, sub-family A (ABC1), member 12

Protein class

 Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (breast, skin)
GTEx:Group enriched (skin, vagina)
FANTOM5:Group enriched (cervix, uterine, epididymis, esophagus, pituitary gland, placenta, tonsil, vagina)

Protein evidence

 Evidence at protein level

DATA RELIABILITY

Reliability score

 Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
N/A
Hippocampus
N/A
N/A
Caudate
N/A
N/A
Cerebellum
N/A
N/A
Endocrine tissues
N/A
Bone marrow & immune system
N/A
Appendix
N/A
Tonsil
N/A
Spleen
N/A
Muscle tissues
N/A
Lung
N/A
Nasopharynx
N/A
N/A
Bronchus
N/A
N/A
Lung
N/A
Liver & gallbladder
N/A
Liver
N/A
Pancreas
N/A
Pancreas
N/A
Gastrointestinal tract
N/A
Oral mucosa
N/A
N/A
Esophagus
N/A
Stomach
N/A
Duodenum
N/A
Colon
N/A
Rectum
N/A
Kidney & urinary bladder
N/A
Kidney
N/A
Male tissues
N/A
Testis
N/A
Prostate
N/A
Female tissues
N/A
Breast
N/A
Vagina
N/A
N/A
Ovary
N/A
Placenta
N/A
Adipose & soft tissue
N/A
Soft tissue
N/A
N/A
Skin
N/A
Skin
N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (breast, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cervix, uterine, epididymis, esophagus, pituitary gland, placenta, tonsil, vagina)

GENE INFORMATION

Gene name

 ABCA12 (HGNC Symbol)

Synonyms

 DKFZP434G232, ICR2B, LI2

Description

 ATP-binding cassette, sub-family A (ABC1), member 12 (HGNC Symbol)

Entrez gene summary

 The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This encoded protein is a member of the ABC1 subfamily, which is the only major ABC subfamily found exclusively in multicellular eukaryotes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 214931542 - 215138428

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144452 (version 83.38)

Entrez gene

 26154

UniProt

 Q86UK0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86UK0

Antibodypedia

 ABCA12 antibodies

PROTEIN BROWSER
ABCA12-001
ABCA12-002
ABCA12-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ABCA12-001
ENSP00000272895
ENST00000272895
Q86UK0 [Direct mapping]
ATP-binding cassette sub-family A member 12
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005743 [mitochondrial inner membrane]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006869 [lipid transport]
GO:0008152 [metabolic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019725 [cellular homeostasis]
GO:0030216 [keratinocyte differentiation]
GO:0031424 [keratinization]
GO:0032940 [secretion by cell]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034040 [lipid-transporting ATPase activity]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0035627 [ceramide transport]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0043129 [surfactant homeostasis]
GO:0045055 [regulated secretory pathway]
GO:0048286 [lung alveolus development]
GO:0055085 [transmembrane transport]
GO:0055088 [lipid homeostasis]
GO:0061436 [establishment of skin barrier]
GO:0072659 [protein localization to plasma membrane]
GO:0097209 [epidermal lamellar body]
GO:2000010 [positive regulation of protein localization to cell surface]
Show all
 2595 aa
293.2 kDa 		No >9
ABCA12-002
ENSP00000374312
ENST00000389661
Q86UK0 [Direct mapping]
ATP-binding cassette sub-family A member 12
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005102 [receptor binding]
GO:0005319 [lipid transporter activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005548 [phospholipid transporter activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006869 [lipid transport]
GO:0008152 [metabolic process]
GO:0010875 [positive regulation of cholesterol efflux]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0017127 [cholesterol transporter activity]
GO:0019725 [cellular homeostasis]
GO:0032940 [secretion by cell]
GO:0033344 [cholesterol efflux]
GO:0033700 [phospholipid efflux]
GO:0034040 [lipid-transporting ATPase activity]
GO:0034191 [apolipoprotein A-I receptor binding]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0045055 [regulated secretory pathway]
GO:0055085 [transmembrane transport]
GO:0072659 [protein localization to plasma membrane]
GO:0097209 [epidermal lamellar body]
Show all
 2277 aa
257 kDa 		No >9
ABCA12-003
ENSP00000400231
ENST00000412081
E9PBK1 [Direct mapping]
ATP-binding cassette sub-family A member 12
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005548 [phospholipid transporter activity]
GO:0005887 [integral component of plasma membrane]
GO:0015914 [phospholipid transport]
GO:0017127 [cholesterol transporter activity]
GO:0033344 [cholesterol efflux]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0055085 [transmembrane transport]
Show all
 90 aa
10.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.