Tissue expression of TRPM8 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TRPM8
Gene description	Transient receptor potential cation channel, subfamily M, member 8
Protein class	FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Voltage-gated ion channels
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (prostate)
GTEx:	Group enriched (liver, prostate)
FANTOM5:	Group enriched (liver, prostate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (prostate)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, prostate)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Group enriched (liver, prostate)

GENE INFORMATION
Gene name	TRPM8
Synonyms
Description	Transient receptor potential cation channel, subfamily M, member 8 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	233917398 - 234019522
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144481 (version 83.38)
Entrez gene	79054
UniProt	Q7Z2W7 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z2W7
Antibodypedia	TRPM8 antibodies

PROTEIN BROWSER

TRPM8-001	TRPM8-002	TRPM8-003	TRPM8-014	TRPM8-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPM8-001 ENSP00000323926 ENST00000324695	Q7Z2W7 [Direct mapping] Transient receptor potential cation channel subfamily M member 8 W8DTH1 [Target identity:100%; Query identity:100%] Transient receptor melastatin 8 Show all	Voltage-gated ion channels Transient Receptor Potential Channels Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0006816 [calcium ion transport] GO:0006874 [cellular calcium ion homeostasis] GO:0009266 [response to temperature stimulus] GO:0009409 [response to cold] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0042803 [protein homodimerization activity] GO:0045121 [membrane raft] GO:0050955 [thermoception] GO:0051289 [protein homotetramerization] GO:0055085 [transmembrane transport] GO:0070207 [protein homotrimerization] GO:0070588 [calcium ion transmembrane transport] Show all	1104 aa 127.7 kDa	No	8
TRPM8-002 ENSP00000347956 ENST00000355722	A0A0C4DFT0 [Direct mapping] Transient receptor potential cation channel subfamily M member 8; Transient receptor potential cation channel, subfamily M, member 8, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0006812 [cation transport] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0050951 [sensory perception of temperature stimulus] Show all	192 aa 21.7 kDa	No	0
TRPM8-003 ENSP00000386771 ENST00000409625	Q7Z2W7 [Direct mapping] Transient receptor potential cation channel subfamily M member 8 Show all	Voltage-gated ion channels Transient Receptor Potential Channels SPOCTOPUS predicted membrane proteins Predicted intracellular proteins FDA approved drug targets Small molecule drugs Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0045121 [membrane raft] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	165 aa 18.7 kDa	No	0
TRPM8-014 ENSP00000414198 ENST00000456930	H0Y7P0 [Direct mapping] Transient receptor potential cation channel subfamily M member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] Show all	376 aa 44.1 kDa	No	5
TRPM8-201 ENSP00000404423 ENST00000433712	A0A0A0MSV2 [Direct mapping] Transient receptor potential cation channel subfamily M member 8 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0006811 [ion transport] GO:0006812 [cation transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016048 [detection of temperature stimulus] GO:0034220 [ion transmembrane transport] GO:0050951 [sensory perception of temperature stimulus] GO:0055085 [transmembrane transport] Show all	753 aa 87.1 kDa	No	5