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DIS3L2

GENERAL INFORMATION

Gene name

 DIS3L2

Gene description

 DIS3 like 3'-5' exoribonuclease 2

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 9
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, most abundant in squamous epithelial cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA035796 , HPA035797
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035796
HPA035797

GENE INFORMATION

Gene name

 DIS3L2 (HGNC Symbol)

Synonyms

 FAM6A, FLJ36974, MGC42174

Description

 DIS3 like 3'-5' exoribonuclease 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar in sequence to 3'/5' exonucleolytic subunits of the RNA exosome. The exosome is a large multimeric ribonucleotide complex responsible for degrading various RNA substrates. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Mar 2012]

Chromosome

 2

Cytoband

 q37.1

Chromosome location (bp)

 231961245 - 232344350

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144535 (version 83.38)

Entrez gene

 129563

UniProt

 Q8IYB7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8IYB7

Antibodypedia

 DIS3L2 antibodies

PROTEIN BROWSER
DIS3L2-001
DIS3L2-003
DIS3L2-007
DIS3L2-008
DIS3L2-010
DIS3L2-011
DIS3L2-012
DIS3L2-015
DIS3L2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DIS3L2-001
ENSP00000273009
ENST00000273009
Q8IYB7 [Direct mapping]
DIS3-like exonuclease 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000287 [magnesium ion binding]
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004540 [ribonuclease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0006364 [rRNA processing]
GO:0007067 [mitotic nuclear division]
GO:0008266 [poly(U) RNA binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010587 [miRNA catabolic process]
GO:0016075 [rRNA catabolic process]
GO:0019827 [stem cell population maintenance]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0051301 [cell division]
GO:0051306 [mitotic sister chromatid separation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1990074 [polyuridylation-dependent mRNA catabolic process]
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 603 aa
67.3 kDa 		No 0
DIS3L2-003
ENSP00000386594
ENST00000409401
Q8IYB7 [Direct mapping]
DIS3-like exonuclease 2
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000287 [magnesium ion binding]
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004540 [ribonuclease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0006364 [rRNA processing]
GO:0007067 [mitotic nuclear division]
GO:0008266 [poly(U) RNA binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010587 [miRNA catabolic process]
GO:0016075 [rRNA catabolic process]
GO:0019827 [stem cell population maintenance]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0051301 [cell division]
GO:0051306 [mitotic sister chromatid separation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1990074 [polyuridylation-dependent mRNA catabolic process]
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 249 aa
27.5 kDa 		No 0
DIS3L2-007
ENSP00000408764
ENST00000417808
H7C302 [Direct mapping]
DIS3-like exonuclease 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006364 [rRNA processing]
GO:0016075 [rRNA catabolic process]
Show all
 68 aa
7.7 kDa 		No 0
DIS3L2-008
ENSP00000390467
ENST00000441279
C9JGP4 [Direct mapping]
DIS3-like exonuclease 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006364 [rRNA processing]
GO:0016075 [rRNA catabolic process]
Show all
 144 aa
16 kDa 		No 0
DIS3L2-010
ENSP00000415419
ENST00000424049
H7C440 [Direct mapping]
DIS3-like exonuclease 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006364 [rRNA processing]
GO:0016075 [rRNA catabolic process]
Show all
 383 aa
43.5 kDa 		No 0
DIS3L2-011
ENSP00000392754
ENST00000434477
H7C036 [Direct mapping]
DIS3-like exonuclease 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006364 [rRNA processing]
GO:0016075 [rRNA catabolic process]
Show all
 196 aa
21.8 kDa 		No 0
DIS3L2-012
ENSP00000401700
ENST00000418143
H7C1Q8 [Direct mapping]
DIS3-like exonuclease 2
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0006364 [rRNA processing]
GO:0016075 [rRNA catabolic process]
Show all
 166 aa
18 kDa 		No 0
DIS3L2-015
ENSP00000386799
ENST00000409307
Q8IYB7 [Direct mapping]
DIS3-like exonuclease 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000287 [magnesium ion binding]
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004540 [ribonuclease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0006364 [rRNA processing]
GO:0007067 [mitotic nuclear division]
GO:0008266 [poly(U) RNA binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010587 [miRNA catabolic process]
GO:0016075 [rRNA catabolic process]
GO:0019827 [stem cell population maintenance]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0051301 [cell division]
GO:0051306 [mitotic sister chromatid separation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1990074 [polyuridylation-dependent mRNA catabolic process]
Show all
 885 aa
99.3 kDa 		No 0
DIS3L2-201
ENSP00000315569
ENST00000325385
Q8IYB7 [Direct mapping]
DIS3-like exonuclease 2
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000176 [nuclear exosome (RNase complex)]
GO:0000177 [cytoplasmic exosome (RNase complex)]
GO:0000287 [magnesium ion binding]
GO:0000291 [nuclear-transcribed mRNA catabolic process, exonucleolytic]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0004540 [ribonuclease activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005844 [polysome]
GO:0006364 [rRNA processing]
GO:0007067 [mitotic nuclear division]
GO:0008266 [poly(U) RNA binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0010587 [miRNA catabolic process]
GO:0016075 [rRNA catabolic process]
GO:0019827 [stem cell population maintenance]
GO:0034427 [nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5']
GO:0051301 [cell division]
GO:0051306 [mitotic sister chromatid separation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
GO:1990074 [polyuridylation-dependent mRNA catabolic process]
Show all
 885 aa
99.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.