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RQCD1

GENERAL INFORMATION

Gene name

 RQCD1

Gene description

 RCD1 required for cell differentiation1 homolog (S. pombe)

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA046622
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA046622

GENE INFORMATION

Gene name

 RQCD1 (HGNC Symbol)

Synonyms

 CAF40, CNOT9, CT129, RCD1, RCD1+

Description

 RCD1 required for cell differentiation1 homolog (S. pombe) (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the highly conserved RCD1 protein family. The encoded protein is a transcriptional cofactor and a core protein of the CCR4-NOT complex. It may be involved in signal transduction as well as retinoic acid-regulated cell differentiation and development. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2012]

Chromosome

 2

Cytoband

 q35

Chromosome location (bp)

 218568580 - 218597080

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144580 (version 83.38)

Entrez gene

 9125

UniProt

 Q92600 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92600

Antibodypedia

 RQCD1 antibodies

PROTEIN BROWSER
RQCD1-001
RQCD1-002
RQCD1-007
RQCD1-008
RQCD1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RQCD1-001
ENSP00000273064
ENST00000273064
Q92600 [Direct mapping]
Cell differentiation protein RCD1 homolog
D5MQE1 [Target identity:100%; Query identity:100%]
RQCD1 protein
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0019904 [protein domain specific binding]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
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 299 aa
33.6 kDa 		Yes 0
RQCD1-002
ENSP00000295701
ENST00000295701
Q92600 [Direct mapping]
Cell differentiation protein RCD1 homolog
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0019904 [protein domain specific binding]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 258 aa
29.1 kDa 		Yes 0
RQCD1-007
ENSP00000396938
ENST00000418808
H7C0W0 [Direct mapping]
Cell differentiation protein RCD1 homolog
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0006402 [mRNA catabolic process]
GO:0030014 [CCR4-NOT complex]
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 61 aa
7.1 kDa 		No 0
RQCD1-008
ENSP00000486540
ENST00000627282
Q92600 [Direct mapping]
Cell differentiation protein RCD1 homolog
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   SCAMPI predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019904 [protein domain specific binding]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 331 aa
36.8 kDa 		Yes 0
RQCD1-201
ENSP00000443687
ENST00000542068
Q92600 [Direct mapping]
Cell differentiation protein RCD1 homolog
D5MQE1 [Target identity:100%; Query identity:100%]
RQCD1 protein
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007548 [sex differentiation]
GO:0010467 [gene expression]
GO:0016020 [membrane]
GO:0017148 [negative regulation of translation]
GO:0019904 [protein domain specific binding]
GO:0030014 [CCR4-NOT complex]
GO:0030015 [CCR4-NOT core complex]
GO:0031047 [gene silencing by RNA]
GO:0033147 [negative regulation of intracellular estrogen receptor signaling pathway]
GO:0042803 [protein homodimerization activity]
GO:2000327 [positive regulation of ligand-dependent nuclear receptor transcription coactivator activity]
Show all
 299 aa
33.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.