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ACKR2
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    TISSUE

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    CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ACKR2

Gene description

Atypical chemokine receptor 2

Protein class

G-protein coupled receptors
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (placenta)
GTEx:Mixed
FANTOM5:Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression mainly in placenta and ciliated cells.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Supported based on 1 antibody.
HPA013819
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)

GENE INFORMATION

Gene name

ACKR2 (HGNC Symbol)

Synonyms

CCBP2, CCR10, CCR9, CMKBR9, D6

Description

Atypical chemokine receptor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]

Chromosome

3

Cytoband

p22.1

Chromosome location (bp)

42804752 - 42887974

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000144648 (version 83.38)

Entrez gene

1238

UniProt

O00590 (UniProt - Evidence at protein level)

neXtProt

NX_O00590

Antibodypedia

ACKR2 antibodies

PROTEIN BROWSER

ACKR2-001
ACKR2-003
ACKR2-007
ACKR2-011
ACKR2-012
ACKR2-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACKR2-001
ENSP00000416996
ENST00000422265
O00590 [Direct mapping]
Atypical chemokine receptor 2
A0A024R2X7 [Target identity:100%; Query identity:100%]
Chemokine binding protein 2, isoform CRA_a
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005515 [protein binding]
GO:0005769 [early endosome]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0019957 [C-C chemokine binding]
GO:0042119 [neutrophil activation]
GO:0055037 [recycling endosome]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
384 aa
43.4 kDa
No 7
ACKR2-003
ENSP00000396150
ENST00000442925
O00590 [Direct mapping]
Atypical chemokine receptor 2
A0A024R2X7 [Target identity:100%; Query identity:100%]
Chemokine binding protein 2, isoform CRA_a
Show all
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0005044 [scavenger receptor activity]
GO:0005769 [early endosome]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006898 [receptor-mediated endocytosis]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007275 [multicellular organismal development]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0042119 [neutrophil activation]
GO:0055037 [recycling endosome]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
384 aa
43.4 kDa
No 7
ACKR2-007
ENSP00000476901
ENST00000497921
V9GYM0 [Direct mapping]
Atypical chemokine receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
125 aa
14.3 kDa
No 2
ACKR2-011
ENSP00000477475
ENST00000492609
V9GZ70 [Direct mapping]
Atypical chemokine receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0004950 [chemokine receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
142 aa
16.3 kDa
No 3
ACKR2-012
ENSP00000477157
ENST00000494619
V9GYX0 [Direct mapping]
Atypical chemokine receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0042119 [neutrophil activation]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
170 aa
19.6 kDa
No 3
ACKR2-013
ENSP00000476581
ENST00000493193
V9GYB7 [Direct mapping]
Atypical chemokine receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016494 [C-X-C chemokine receptor activity]
GO:0042119 [neutrophil activation]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
233 aa
26.8 kDa
No 5

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The Human Protein Atlas project is funded
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