Expression of CTDSPL in cancer - Summary - The Human Protein Atlas

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CTDSPL

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CTDSPL
Gene description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (hTCEpi)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in vessels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in vessels are not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA048325
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048325

GENE INFORMATION
Gene name	CTDSPL (HGNC Symbol)
Synonyms	C3orf8, HYA22, PSR1, RBSP3, SCP3
Description	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	37861960 - 37984469
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144677 (version 83.38)
Entrez gene	10217
UniProt	O15194 (UniProt - Evidence at protein level)
neXtProt	NX_O15194
Antibodypedia	CTDSPL antibodies

PROTEIN BROWSER

CTDSPL-001	CTDSPL-002	CTDSPL-007	CTDSPL-008	CTDSPL-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CTDSPL-001 ENSP00000273179 ENST00000273179	O15194 [Direct mapping] CTD small phosphatase-like protein Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001933 [negative regulation of protein phosphorylation] GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008150 [biological_process] GO:0008420 [CTD phosphatase activity] GO:0016791 [phosphatase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] GO:2000134 [negative regulation of G1/S transition of mitotic cell cycle] Show all	276 aa 31.1 kDa	No	0
CTDSPL-002 ENSP00000398288 ENST00000443503	O15194 [Direct mapping] CTD small phosphatase-like protein Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005634 [nucleus] GO:0006470 [protein dephosphorylation] GO:0008150 [biological_process] GO:0008420 [CTD phosphatase activity] GO:0016791 [phosphatase activity] GO:0046872 [metal ion binding] GO:0070062 [extracellular exosome] Show all	265 aa 29.9 kDa	No	0
CTDSPL-007 ENSP00000404977 ENST00000416688	H7C2B9 [Direct mapping] CTD small phosphatase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.1 kDa	No	0
CTDSPL-008 ENSP00000407443 ENST00000447745	H7C2S4 [Direct mapping] CTD small phosphatase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] Show all	196 aa 22.3 kDa	No	0
CTDSPL-009 ENSP00000409600 ENST00000436654	H7C353 [Direct mapping] CTD small phosphatase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		103 aa 11.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.