Expression of STAC in cancer - Summary - The Human Protein Atlas

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STAC

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STAC
Gene description	SH3 and cysteine rich domain
Protein class	Predicted intracellular proteins Transporters
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, SH-SY5Y, U-87 MG)
HPA (normal tissue):	Tissue enhanced (parathyroid gland, prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA035143
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035143

GENE INFORMATION
Gene name	STAC (HGNC Symbol)
Synonyms	STAC1
Description	SH3 and cysteine rich domain (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband
Chromosome location (bp)	36380344 - 36548007
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144681 (version 83.38)
Entrez gene	6769
UniProt	Q99469 (UniProt - Evidence at protein level)
neXtProt	NX_Q99469
Antibodypedia	STAC antibodies

PROTEIN BROWSER

STAC-001	STAC-003	STAC-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STAC-001 ENSP00000273183 ENST00000273183	Q99469 [Direct mapping] SH3 and cysteine-rich domain-containing protein Show all	Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0034605 [cellular response to heat] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	402 aa 44.6 kDa	No	0
STAC-003 ENSP00000393713 ENST00000457375	E9PEA7 [Direct mapping] SH3 and cysteine-rich domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	341 aa 37.7 kDa	No	0
STAC-007 ENSP00000398403 ENST00000434649	C9J3Z9 [Direct mapping] SH3 and cysteine-rich domain-containing protein Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	252 aa 27.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.