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CAND2

GENERAL INFORMATION

Gene name

 CAND2

Gene description

 Cullin-associated and neddylation-dissociated 2 (putative)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HEK93, REH)
HPA (normal tissue):Tissue enhanced (skeletal muscle, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in testis, skeletal muscle and heart muscle.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA005777
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005777

GENE INFORMATION

Gene name

 CAND2 (HGNC Symbol)

Synonyms

 KIAA0667, TIP120B, Tp120b

Description

 Cullin-associated and neddylation-dissociated 2 (putative) (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p25.2

Chromosome location (bp)

 12796472 - 12871916

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144712 (version 83.38)

Entrez gene

 23066

UniProt

 O75155 (UniProt - Evidence at protein level)

neXtProt

 NX_O75155

Antibodypedia

 CAND2 antibodies

PROTEIN BROWSER
CAND2-001
CAND2-002
CAND2-006
CAND2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAND2-001
ENSP00000295989
ENST00000295989
O75155 [Direct mapping]
Cullin-associated NEDD8-dissociated protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0010265 [SCF complex assembly]
GO:0016567 [protein ubiquitination]
GO:0045893 [positive regulation of transcription, DNA-templated]
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 1119 aa
122.7 kDa 		No 0
CAND2-002
ENSP00000387641
ENST00000456430
O75155 [Direct mapping]
Cullin-associated NEDD8-dissociated protein 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0010265 [SCF complex assembly]
GO:0016567 [protein ubiquitination]
GO:0017025 [TBP-class protein binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
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 1236 aa
135.3 kDa 		No 0
CAND2-006
ENSP00000403093
ENST00000454887
C9JH00 [Direct mapping]
Cullin-associated NEDD8-dissociated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0010265 [SCF complex assembly]
GO:0016567 [protein ubiquitination]
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 163 aa
18.4 kDa 		No 0
CAND2-201
ENSP00000486760
ENST00000626378
F8WBB8 [Direct mapping]
Cullin-associated NEDD8-dissociated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0010265 [SCF complex assembly]
GO:0016567 [protein ubiquitination]
Show all
 110 aa
12.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.