Expression of IL17RD in cancer - Summary - The Human Protein Atlas

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IL17RD

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL17RD
Gene description	Interleukin 17 receptor D
Protein class	Disease related genes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (AF22, AN3-CA, NTERA-2, SH-SY5Y)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA039577 , HPA043550
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039577	HPA043550

GENE INFORMATION
Gene name	IL17RD (HGNC Symbol)
Synonyms	FLJ35755, IL-17RD, IL17RLM, SEF
Description	Interleukin 17 receptor D (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin (PMID: 19079364). The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling (PMID: 21663947, 18096367). [provided by RefSeq, Nov 2011]
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	57089982 - 57170306
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144730 (version 83.38)
Entrez gene	54756
UniProt	Q8NFM7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFM7
Antibodypedia	IL17RD antibodies

PROTEIN BROWSER

IL17RD-001	IL17RD-002	IL17RD-003	IL17RD-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL17RD-001 ENSP00000322250 ENST00000320057	Q8NFM7 [Direct mapping] Interleukin-17 receptor D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	595 aa 66.8 kDa	No	1
IL17RD-002 ENSP00000296318 ENST00000296318	Q8NFM7 [Direct mapping] Interleukin-17 receptor D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	739 aa 82.4 kDa	Yes	1
IL17RD-003 ENSP00000417516 ENST00000463523	Q8NFM7 [Direct mapping] Interleukin-17 receptor D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Show all	GO:0000139 [Golgi membrane] GO:0000165 [MAPK cascade] GO:0000186 [activation of MAPKK activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005794 [Golgi apparatus] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007265 [Ras protein signal transduction] GO:0007411 [axon guidance] GO:0008286 [insulin receptor signaling pathway] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0045087 [innate immune response] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	595 aa 66.8 kDa	No	1
IL17RD-006 ENSP00000418368 ENST00000467210	C9J6R0 [Direct mapping] Interleukin-17 receptor D Show all	Predicted intracellular proteins Show all	GO:0005887 [integral component of plasma membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0030368 [interleukin-17 receptor activity] Show all	73 aa 8.6 kDa	No	0

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