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ARL6IP5

GENERAL INFORMATION

Gene name

 ARL6IP5

Gene description

 ADP-ribosylation factor-like 6 interacting protein 5

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA015540 , CAB019321
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Breast

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 ARL6IP5 (HGNC Symbol)

Synonyms

 DERP11, GTRAP3-18, HSPC127, JWA, PRAF3

Description

 ADP-ribosylation factor-like 6 interacting protein 5 (HGNC Symbol)

Entrez gene summary

 Expression of this gene is affected by vitamin A. The encoded protein of this gene may be associated with the cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p14.1

Chromosome location (bp)

 69084944 - 69106066

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144746 (version 83.38)

Entrez gene

 10550

UniProt

 O75915 (UniProt - Evidence at protein level)

neXtProt

 NX_O75915

Antibodypedia

 ARL6IP5 antibodies

PROTEIN BROWSER
ARL6IP5-001
ARL6IP5-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARL6IP5-001
ENSP00000273258
ENST00000273258
O75915 [Direct mapping]
PRA1 family protein 3
A0A024R371 [Target identity:100%; Query identity:100%]
ADP-ribosylation-like factor 6 interacting protein 5, isoform CRA_a
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0008631 [intrinsic apoptotic signaling pathway in response to oxidative stress]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015813 [L-glutamate transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0032874 [positive regulation of stress-activated MAPK cascade]
GO:0043065 [positive regulation of apoptotic process]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0070062 [extracellular exosome]
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 188 aa
21.6 kDa 		No 3
ARL6IP5-002
ENSP00000420138
ENST00000478935
C9JQU6 [Direct mapping]
PRA1 family protein 3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 88 aa
10.3 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.