Expression of NFKBIZ in cancer - Summary - The Human Protein Atlas

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NFKBIZ

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NFKBIZ
Gene description	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ hTERT+)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in subset of immune cells, most abundant in bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA010547
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Cervical cancer

STAINING SUMMARY

HPA010547

GENE INFORMATION
Gene name	NFKBIZ (HGNC Symbol)
Synonyms	FLJ34463, INAP, MAIL
Description	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta (HGNC Symbol)
Entrez gene summary	This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	3
Cytoband	q12.3
Chromosome location (bp)	101827991 - 101861022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144802 (version 83.38)
Entrez gene	64332
UniProt	Q9BYH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYH8
Antibodypedia	NFKBIZ antibodies

PROTEIN BROWSER

NFKBIZ-001	NFKBIZ-002	NFKBIZ-003	NFKBIZ-004	NFKBIZ-005	NFKBIZ-011	NFKBIZ-012

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NFKBIZ-001 ENSP00000377618 ENST00000394054	Q9BYH8 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	618 aa 68.2 kDa	No	0
NFKBIZ-002 ENSP00000325593 ENST00000326151	Q9BYH8 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	596 aa 64.3 kDa	No	0
NFKBIZ-003 ENSP00000325663 ENST00000326172	Q9BYH8 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] Show all	718 aa 78.1 kDa	No	0
NFKBIZ-004 ENSP00000419800 ENST00000483180	C9JZ23 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	601 aa 66.2 kDa	No	0
NFKBIZ-005 ENSP00000418502 ENST00000461724	C9J5G8 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	110 aa 10.9 kDa	No	0
NFKBIZ-011 ENSP00000418498 ENST00000491281	C9J5I7 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	130 aa 14.4 kDa	No	0
NFKBIZ-012 ENSP00000420700 ENST00000477601	H7C5S1 [Direct mapping] NF-kappa-B inhibitor zeta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	130 aa 14.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.