Expression of IGSF11 in cancer - Summary - The Human Protein Atlas

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IGSF11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGSF11
Gene description	Immunoglobulin superfamily, member 11
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, melanoma)
HPA (cell line):	Cell line enhanced (A549, SK-MEL-30, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA046377
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046377

GENE INFORMATION
Gene name	IGSF11 (HGNC Symbol)
Synonyms	BT-IgSF, CT119, Igsf13, MGC35227, VSIG3
Description	Immunoglobulin superfamily, member 11 (HGNC Symbol)
Entrez gene summary	IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]
Chromosome	3
Cytoband	q13.32
Chromosome location (bp)	118900557 - 119146068
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000144847 (version 83.38)
Entrez gene	152404
UniProt	Q5DX21 (UniProt - Evidence at transcript level)
neXtProt	NX_Q5DX21
Antibodypedia	IGSF11 antibodies

PROTEIN BROWSER

IGSF11-001	IGSF11-002	IGSF11-003	IGSF11-004	IGSF11-005	IGSF11-006	IGSF11-007	IGSF11-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGSF11-001 ENSP00000406092 ENST00000425327	Q5DX21 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] GO:0070062 [extracellular exosome] Show all	430 aa 46.2 kDa	Yes	1
IGSF11-002 ENSP00000377370 ENST00000393775	Q5DX21 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] GO:0070062 [extracellular exosome] Show all	431 aa 46.1 kDa	Yes	1
IGSF11-003 ENSP00000401240 ENST00000441144	Q5DX21 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] GO:0070062 [extracellular exosome] Show all	406 aa 43.8 kDa	Yes	1
IGSF11-004 ENSP00000420486 ENST00000489689	C9JMW0 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	407 aa 43.6 kDa	Yes	1
IGSF11-005 ENSP00000417413 ENST00000491903	C9JBA5 [Direct mapping] Immunoglobulin superfamily member 11 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] Show all	403 aa 43.4 kDa	Yes	0
IGSF11-006 ENSP00000418047 ENST00000480431	C9JAD3 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted intracellular proteins Show all		33 aa 3.7 kDa	No	0
IGSF11-007 ENSP00000418976 ENST00000483401	C9IZX3 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	59 aa 6.4 kDa	No	0
IGSF11-201 ENSP00000346700 ENST00000354673	Q5DX21 [Direct mapping] Immunoglobulin superfamily member 11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0040008 [regulation of growth] GO:0070062 [extracellular exosome] Show all	430 aa 46.2 kDa	Yes	1

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The Human Protein Atlas

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