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Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)
HPA (cell line):
Group enriched (Hep G2, RH-30)
HPA (normal tissue):
Group enriched (colon, duodenum, gallbladder, liver, rectum, small intestine)
Protein evidence
Evidence at protein level
ANTIBODY IHC RELIABILITY
Reliability score
Pending cancer tissue analysis.
PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, liver cancer, pancreatic cancer, stomach cancer)
PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY
GENE INFORMATION
Gene name
NR1I2 (HGNC Symbol)
Synonyms
BXR, ONR1, PAR2, PXR, SXR
Description
Nuclear receptor subfamily 1, group I, member 2 (HGNC Symbol)
Entrez gene summary
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008]
O75469 [Direct mapping] Nuclear receptor subfamily 1 group I member 2 F1D8P9 [Target identity:100%; Query identity:100%] Nuclear receptor subfamily 1, group I, member 2, isoform CRA_b; Pregnane X nuclear receptor variant 2
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Nuclear receptors Predicted intracellular proteins Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains FDA approved drug targets Small molecule drugs
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006805 [xenobiotic metabolic process] GO:0007165 [signal transduction] GO:0008144 [drug binding] GO:0008202 [steroid metabolic process] GO:0008270 [zinc ion binding] GO:0010467 [gene expression] GO:0010628 [positive regulation of gene expression] GO:0030522 [intracellular receptor signaling pathway] GO:0042738 [exogenous drug catabolic process] GO:0042908 [xenobiotic transport] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046618 [drug export]
