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TRPC1

GENERAL INFORMATION

Gene name

 TRPC1

Gene description

 Transient receptor potential cation channel, subfamily C, member 1

Protein class

 Predicted membrane proteins
Transporters
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021130 , CAB009387
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA021130
CAB009387

GENE INFORMATION

Gene name

 TRPC1 (HGNC Symbol)

Synonyms

 HTRP-1

Description

 Transient receptor potential cation channel, subfamily C, member 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 3

Cytoband

 q23

Chromosome location (bp)

 142724074 - 142807888

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000144935 (version 83.38)

Entrez gene

 7220

UniProt

 P48995 (UniProt - Evidence at protein level)

neXtProt

 NX_P48995

Antibodypedia

 TRPC1 antibodies

PROTEIN BROWSER
TRPC1-001
TRPC1-002
TRPC1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPC1-001
ENSP00000273482
ENST00000273482
P48995 [Direct mapping]
Short transient receptor potential channel 1
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Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0042438 [melanin biosynthetic process]
GO:0043235 [receptor complex]
GO:0044325 [ion channel binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
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 759 aa
87.6 kDa 		No 8
TRPC1-002
ENSP00000419313
ENST00000476941
P48995 [Direct mapping]
Short transient receptor potential channel 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0015279 [store-operated calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016323 [basolateral plasma membrane]
GO:0030017 [sarcomere]
GO:0034220 [ion transmembrane transport]
GO:0042438 [melanin biosynthetic process]
GO:0043034 [costamere]
GO:0043234 [protein complex]
GO:0043235 [receptor complex]
GO:0044325 [ion channel binding]
GO:0045121 [membrane raft]
GO:0046541 [saliva secretion]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
GO:0071456 [cellular response to hypoxia]
Show all
 793 aa
91.2 kDa 		No 8
TRPC1-201
ENSP00000481537
ENST00000612385
P48995 [Direct mapping]
Short transient receptor potential channel 1
Show all
Transporters
   Transporter channels and pores
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006828 [manganese ion transport]
GO:0007411 [axon guidance]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0042438 [melanin biosynthetic process]
GO:0043235 [receptor complex]
GO:0044325 [ion channel binding]
GO:0051281 [positive regulation of release of sequestered calcium ion into cytosol]
GO:0051480 [cytosolic calcium ion homeostasis]
GO:0051592 [response to calcium ion]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0070679 [inositol 1,4,5 trisphosphate binding]
Show all
 759 aa
87.6 kDa 		No 8

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.