Expression of LPP in cancer - Summary - The Human Protein Atlas

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LPP

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LPP
Gene description	LIM domain containing preferred translocation partner in lipoma
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, U-698)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several cell types, most abundant in smooth muscle cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA011133 , HPA017342
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011133	HPA017342

GENE INFORMATION
Gene name	LPP
Synonyms
Description	LIM domain containing preferred translocation partner in lipoma (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Chromosome	3
Cytoband
Chromosome location (bp)	188153284 - 188890671
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145012 (version 83.38)
Entrez gene	4026
UniProt	Q93052 (UniProt - Evidence at protein level)
neXtProt	NX_Q93052
Antibodypedia	LPP antibodies

PROTEIN BROWSER

LPP-001	LPP-002	LPP-004	LPP-005	LPP-006	LPP-007	LPP-008	LPP-009	LPP-011	LPP-012	LPP-019	LPP-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LPP-001 ENSP00000482617 ENST00000618621	A0A087WZF1 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	590 aa 63.4 kDa	No	0
LPP-002 ENSP00000393602 ENST00000448637	C9JUT4 [Direct mapping] LIM domain containing preferred translocation partner in lipoma, isoform CRA_e; Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] Show all	428 aa 45.3 kDa	No	0
LPP-004 ENSP00000410340 ENST00000416784	C9J4E3 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		151 aa 16 kDa	No	0
LPP-005 ENSP00000397166 ENST00000430340	C9J2R5 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.7 kDa	No	0
LPP-006 ENSP00000392667 ENST00000414139	C9J1K7 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		93 aa 9.8 kDa	No	0
LPP-007 ENSP00000394257 ENST00000454789	C9JT42 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		65 aa 7 kDa	No	0
LPP-008 ENSP00000397017 ENST00000426274	C9J3U9 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.1 kDa	No	0
LPP-009 ENSP00000405138 ENST00000420410	C9J5C8 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		111 aa 11.8 kDa	No	0
LPP-011 ENSP00000404679 ENST00000443217	C9JE51 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.1 kDa	No	0
LPP-012 ENSP00000403825 ENST00000457242	C9JIY7 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.2 kDa	No	0
LPP-019 ENSP00000393008 ENST00000415906	C9JXK9 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005925 [focal adhesion] Show all	252 aa 26.7 kDa	No	0
LPP-201 ENSP00000478901 ENST00000617246	Q93052 [Direct mapping] Lipoma-preferred partner Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] GO:0008150 [biological_process] GO:0008270 [zinc ion binding] Show all	612 aa 65.7 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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