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RUBCN

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GENERAL INFORMATION

Gene name

 RUBCN

Gene description

 RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the cytosol & vesicles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Vesicles (supported), Cytosol (approved)

Mouse

 Localized to the Vesicles, Cytosol in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050908
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the cytosol & vesicles.

Main location

 Vesicles (supported), Cytosol (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050908 A-431 Nucleoplasm
Vesicles
Cytosol
HPA050908 MCF7 Nucleoplasm
Cytosol
HPA050908 U-2 OS Nucleoplasm
Vesicles
Cytosol

MOUSE CELLS

Main location

 Vesicles, Cytosol

Mouse gene

 ENSMUSG00000035629 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA050908 NIH 3T3 Vesicles
Cytosol

GENE INFORMATION

Gene name

 RUBCN (HGNC Symbol)

Synonyms

 KIAA0226, rubicon, rundataxin

Description

 RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a negative regulator of autophagy and endocytic trafficking and controls endosome maturation. This protein contains two conserved domains, an N-terminal RUN domain and a C-terminal DUF4206 domain. The RUN domain is involved in Ras-like GTPase signaling, and the DUF4206 domain contains a diacylglycerol (DAG) binding-like motif. Mutation in this gene results in deletion of the DAG binding-like motif and causes a recessive ataxia. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

Chromosome

 3

Cytoband

 q29

Chromosome location (bp)

 197671393 - 197749727

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145016 (version 83.38)

Entrez gene

 9711

UniProt

 Q92622 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92622

Antibodypedia

 RUBCN antibodies

PROTEIN BROWSER
RUBCN-001
RUBCN-003
RUBCN-004
RUBCN-005
RUBCN-008
RUBCN-009
RUBCN-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RUBCN-001
ENSP00000273582
ENST00000273582
Q92622 [Direct mapping]
Run domain Beclin-1 interacting and cysteine-rich containing protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0006909 [phagocytosis]
GO:0006914 [autophagy]
GO:0010507 [negative regulation of autophagy]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0045806 [negative regulation of endocytosis]
GO:1901097 [negative regulation of autophagosome maturation]
Show all
 927 aa
103.5 kDa 		No 0
RUBCN-003
ENSP00000390962
ENST00000449205
E9PEM3 [Direct mapping]
Run domain Beclin-1-interacting and cysteine-rich-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 435 aa
47.5 kDa 		No 0
RUBCN-004
ENSP00000409618
ENST00000415452
H7C357 [Direct mapping]
Run domain Beclin-1-interacting and cysteine-rich-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 680 aa
75.1 kDa 		No 0
RUBCN-005
ENSP00000405115
ENST00000413360
H0Y6E6 [Direct mapping]
Run domain Beclin-1-interacting and cysteine-rich-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 934 aa
104.3 kDa 		No 0
RUBCN-008
ENSP00000485041
ENST00000474214
A0A096LNI3 [Direct mapping]
Run domain Beclin-1-interacting and cysteine-rich-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 25 aa
2.8 kDa 		No 0
RUBCN-009
ENSP00000411894
ENST00000447048
H7C3H3 [Direct mapping]
Run domain Beclin-1-interacting and cysteine-rich-containing protein
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 147 aa
16.3 kDa 		No 0
RUBCN-011
ENSP00000296343
ENST00000296343
Q92622 [Direct mapping]
Run domain Beclin-1 interacting and cysteine-rich containing protein
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005764 [lysosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005794 [Golgi apparatus]
GO:0006909 [phagocytosis]
GO:0006914 [autophagy]
GO:0010507 [negative regulation of autophagy]
GO:0043553 [negative regulation of phosphatidylinositol 3-kinase activity]
GO:0045806 [negative regulation of endocytosis]
GO:1901097 [negative regulation of autophagosome maturation]
Show all
 972 aa
108.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.