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VPRBP

GENERAL INFORMATION

Gene name

 VPRBP

Gene description

 Vpr (HIV-1) binding protein

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036142 , HPA053203
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036142
HPA053203

GENE INFORMATION

Gene name

 VPRBP (HGNC Symbol)

Synonyms

 DCAF1, KIAA0800, MGC102804

Description

 Vpr (HIV-1) binding protein (HGNC Symbol)

Entrez gene summary

Chromosome

 3

Cytoband

 p21.2

Chromosome location (bp)

 51395867 - 51500002

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145041 (version 83.38)

Entrez gene

 9730

UniProt

 Q9Y4B6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4B6

Antibodypedia

 VPRBP antibodies

PROTEIN BROWSER
VPRBP-001
VPRBP-201
VPRBP-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPRBP-001
ENSP00000393183
ENST00000423656
Q9Y4B6 [Direct mapping]
Protein VPRBP
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Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008180 [COP9 signalosome]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0030183 [B cell differentiation]
GO:0033151 [V(D)J recombination]
GO:0035212 [cell competition in a multicellular organism]
GO:1990244 [histone kinase activity (H2A-T120 specific)]
GO:1990245 [histone H2A-T120 phosphorylation]
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 1507 aa
169 kDa 		No 0
VPRBP-201
ENSP00000338857
ENST00000335891
Q9Y4B6 [Direct mapping]
Protein VPRBP
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008180 [COP9 signalosome]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0030183 [B cell differentiation]
GO:0033151 [V(D)J recombination]
GO:0035212 [cell competition in a multicellular organism]
GO:1990244 [histone kinase activity (H2A-T120 specific)]
GO:1990245 [histone H2A-T120 phosphorylation]
Show all
 1058 aa
118.2 kDa 		No 0
VPRBP-202
ENSP00000421724
ENST00000504652
Q9Y4B6 [Direct mapping]
Protein VPRBP
Show all
Enzymes
   ENZYME proteins
   Transferases
   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0008180 [COP9 signalosome]
GO:0016032 [viral process]
GO:0016567 [protein ubiquitination]
GO:0030183 [B cell differentiation]
GO:0033151 [V(D)J recombination]
GO:0035212 [cell competition in a multicellular organism]
GO:1990244 [histone kinase activity (H2A-T120 specific)]
GO:1990245 [histone H2A-T120 phosphorylation]
Show all
 1506 aa
168.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.