Expression of MANF in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MANF

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MANF
Gene description	Mesencephalic astrocyte-derived neurotrophic factor
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, highest in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA011175
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011175

GENE INFORMATION
Gene name	MANF (HGNC Symbol)
Synonyms	ARMET, ARP
Description	Mesencephalic astrocyte-derived neurotrophic factor (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related. [provided by RefSeq, Apr 2014]
Chromosome	3
Cytoband	p21.2
Chromosome location (bp)	51385047 - 51389397
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145050 (version 83.38)
Entrez gene	7873
UniProt
neXtProt
Antibodypedia	MANF antibodies

PROTEIN BROWSER

MANF-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MANF-001 ENSP00000432799 ENST00000528157	A8K878 [Direct mapping] Mesencephalic astrocyte-derived neurotrophic factor; cDNA FLJ77177, highly similar to Homo sapiens arginine-rich, mutated in early stage tumors (ARMET), mRNA Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002014 [vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0048471 [perinuclear region of cytoplasm] Show all	185 aa 21.1 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.