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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EAF2
  • premium

    TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EAF2

Gene description

ELL associated factor 2

Protein class

Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HL-60, U-698)
HPA (normal tissue):Tissue enhanced (lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

Supported based on 1 antibody.
HPA008411
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PROGNOSTIC SUMMARY

Prognostic marker in cervical cancer (favourable) and endometrial cancer (favourable).
Cervical cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA008411

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate nuclear staining was displayed in most cases of lymphoma. Weak to moderate cytoplasmic or nuclear positivity was observed in tumor cells in a few cases of several other cancer types.

GENE INFORMATION

Gene name

EAF2 (HGNC Symbol)

Synonyms

BM040, TRAITS, U19

Description

ELL associated factor 2 (HGNC Symbol)

Entrez gene summary

Chromosome

3

Cytoband

q13.33

Chromosome location (bp)

121835183 - 121886526

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145088 (version 83.38)

Entrez gene

55840

UniProt

Q96CJ1 (UniProt - Evidence at protein level)

neXtProt

NX_Q96CJ1

Antibodypedia

EAF2 antibodies

PROTEIN BROWSER

EAF2-001
EAF2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EAF2-001
ENSP00000273668
ENST00000273668
Q96CJ1 [Direct mapping]
ELL-associated factor 2
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Predicted intracellular proteins
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GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0008023 [transcription elongation factor complex]
GO:0016607 [nuclear speck]
GO:0030308 [negative regulation of cell growth]
GO:0032783 [ELL-EAF complex]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
Show all
260 aa
28.8 kDa
No 0
EAF2-004
ENSP00000410708
ENST00000451944
B4DWJ3 [Direct mapping]
ELL-associated factor 2; cDNA FLJ60185, highly similar to ELL-associated factor 2
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Predicted intracellular proteins
Show all
GO:0006355 [regulation of transcription, DNA-templated]
GO:0032783 [ELL-EAF complex]
Show all
263 aa
29.2 kDa
No 0

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