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Most cases of cervical cancer as well as several cases of colorectal, ovarian, endometrial, lung, gastric and pancreatic cancers showed moderate to strong cytoplasmic positivity. Other cancer tissues were in general weakly stained or negative.
Several cases of cervical, endometrial, lung and pancreatic cancers displayed moderate to strong cytoplasmic and membranous positivity. Most remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
MUC4
Synonyms
Description
Mucin 4, cell surface associated (HGNC Symbol)
Entrez gene summary
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008]