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RNA-based expert annotation could not be performed, due to inconclusive results. View immunohistochemistry primary data.
RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GENE INFORMATION
Gene name
SLIT2 (HGNC Symbol)
Synonyms
SLIL3, Slit-2
Description
Slit guidance ligand 2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the slit family of secreted glycoproteins, which are ligands for the Robo family of immunoglobulin receptors. Slit proteins play highly conserved roles in axon guidance and neuronal migration and may also have functions during other cell migration processes including leukocyte migration. Members of the slit family are characterized by an N-terminal signal peptide, four leucine-rich repeats, nine epidermal growth factor repeats, and a C-terminal cysteine knot. Proteolytic processing of this protein gives rise to an N-terminal fragment that contains the four leucine-rich repeats and five epidermal growth factor repeats and a C-terminal fragment that contains four epidermal growth factor repeats and the cysteine knot. Both full length and cleaved proteins are secreted extracellularly and can function in axon repulsion as well as other specific processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
O94813 [Direct mapping] Slit homolog 2 protein Slit homolog 2 protein N-product Slit homolog 2 protein C-product
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001656 [metanephros development] GO:0001657 [ureteric bud development] GO:0001701 [in utero embryonic development] GO:0001933 [negative regulation of protein phosphorylation] GO:0002042 [cell migration involved in sprouting angiogenesis] GO:0002689 [negative regulation of leukocyte chemotaxis] GO:0005095 [GTPase inhibitor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007409 [axonogenesis] GO:0007411 [axon guidance] GO:0007420 [brain development] GO:0008045 [motor neuron axon guidance] GO:0008201 [heparin binding] GO:0008285 [negative regulation of cell proliferation] GO:0009986 [cell surface] GO:0010593 [negative regulation of lamellipodium assembly] GO:0010596 [negative regulation of endothelial cell migration] GO:0010629 [negative regulation of gene expression] GO:0014912 [negative regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0016337 [single organismal cell-cell adhesion] GO:0021510 [spinal cord development] GO:0021772 [olfactory bulb development] GO:0021836 [chemorepulsion involved in postnatal olfactory bulb interneuron migration] GO:0021972 [corticospinal neuron axon guidance through spinal cord] GO:0022029 [telencephalon cell migration] GO:0030308 [negative regulation of cell growth] GO:0030336 [negative regulation of cell migration] GO:0030517 [negative regulation of axon extension] GO:0030837 [negative regulation of actin filament polymerization] GO:0031290 [retinal ganglion cell axon guidance] GO:0031667 [response to nutrient levels] GO:0032870 [cellular response to hormone stimulus] GO:0033563 [dorsal/ventral axon guidance] GO:0034260 [negative regulation of GTPase activity] GO:0035385 [Roundabout signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043065 [positive regulation of apoptotic process] GO:0043116 [negative regulation of vascular permeability] GO:0043237 [laminin-1 binding] GO:0043394 [proteoglycan binding] GO:0043395 [heparan sulfate proteoglycan binding] GO:0045499 [chemorepellent activity] GO:0048495 [Roundabout binding] GO:0048754 [branching morphogenesis of an epithelial tube] GO:0048812 [neuron projection morphogenesis] GO:0048846 [axon extension involved in axon guidance] GO:0050728 [negative regulation of inflammatory response] GO:0050772 [positive regulation of axonogenesis] GO:0050919 [negative chemotaxis] GO:0050929 [induction of negative chemotaxis] GO:0051058 [negative regulation of small GTPase mediated signal transduction] GO:0051414 [response to cortisol] GO:0060603 [mammary gland duct morphogenesis] GO:0060763 [mammary duct terminal end bud growth] GO:0061364 [apoptotic process involved in luteolysis] GO:0070062 [extracellular exosome] GO:0070100 [negative regulation of chemokine-mediated signaling pathway] GO:0071504 [cellular response to heparin] GO:0071672 [negative regulation of smooth muscle cell chemotaxis] GO:0071676 [negative regulation of mononuclear cell migration] GO:0090024 [negative regulation of neutrophil chemotaxis] GO:0090027 [negative regulation of monocyte chemotaxis] GO:0090260 [negative regulation of retinal ganglion cell axon guidance] GO:0090288 [negative regulation of cellular response to growth factor stimulus]