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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EIF2B5
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EIF2B5

Gene description

Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa

Protein class

Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Uncertain based on 1 antibody.
CAB015412
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB015412

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignancies showed weak to moderate cytoplasmic staining. Colorectal, breast, prostate, endometrial, and renal cancers were generally negative.

GENE INFORMATION

Gene name

EIF2B5 (HGNC Symbol)

Synonyms

EIF-2B, EIF2Bepsilon

Description

Eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa (HGNC Symbol)

Entrez gene summary

This gene encodes one of five subunits of eukaryotic translation initiation factor 2B (EIF2B), a GTP exchange factor for eukaryotic initiation factor 2 and an essential regulator for protein synthesis. Mutations in this gene and the genes encoding other EIF2B subunits have been associated with leukoencephalopathy with vanishing white matter. [provided by RefSeq, Nov 2009]

Chromosome

3

Cytoband

q27.1

Chromosome location (bp)

184135038 - 184684758

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145191 (version 83.38)

Entrez gene

8893

UniProt

Q13144 (UniProt - Evidence at protein level)

neXtProt

NX_Q13144

Antibodypedia

EIF2B5 antibodies

PROTEIN BROWSER

EIF2B5-001
EIF2B5-003
EIF2B5-017

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EIF2B5-001
ENSP00000273783
ENST00000273783
Q13144 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001541 [ovarian follicle development]
GO:0003743 [translation initiation factor activity]
GO:0005085 [guanyl-nucleotide exchange factor activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005851 [eukaryotic translation initiation factor 2B complex]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006417 [regulation of translation]
GO:0007568 [aging]
GO:0009408 [response to heat]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0014002 [astrocyte development]
GO:0014003 [oligodendrocyte development]
GO:0031369 [translation initiation factor binding]
GO:0032057 [negative regulation of translational initiation in response to stress]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035690 [cellular response to drug]
GO:0042552 [myelination]
GO:0043434 [response to peptide hormone]
GO:0043547 [positive regulation of GTPase activity]
GO:0044267 [cellular protein metabolic process]
GO:0045948 [positive regulation of translational initiation]
GO:0048708 [astrocyte differentiation]
Show all
721 aa
80.4 kDa
No 0
EIF2B5-003
ENSP00000414775
ENST00000432569
C9JRD9 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
107 aa
11.2 kDa
No 0
EIF2B5-017
ENSP00000409142
ENST00000444495
E9PC74 [Direct mapping]
Translation initiation factor eIF-2B subunit epsilon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005488 [binding]
GO:0005515 [protein binding]
Show all
705 aa
78.3 kDa
No 0

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