Expression of ECE2 in cancer - Summary - The Human Protein Atlas

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ECE2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ECE2
Gene description	Endothelin converting enzyme 2
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA043346
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and liver cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA043346

GENE INFORMATION
Gene name	ECE2 (HGNC Symbol)
Synonyms	KIAA0604, MGC2408
Description	Endothelin converting enzyme 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the M13 family, which includes type 2 integral membrane metallopeptidases. The encoded enzyme is a membrane-bound zinc-dependent metalloprotease. The enzyme catalyzes the cleavage of big endothelin to produce the vasoconstrictor endothelin-1, and plays a role in the processing of several neuroendocrine peptides. It may also have methyltransferase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	3
Cytoband	q27.1
Chromosome location (bp)	184249650 - 184293031
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145194 (version 83.38)
Entrez gene	9718
UniProt	O60344 (UniProt - Evidence at protein level)
neXtProt	NX_O60344
Antibodypedia	ECE2 antibodies

PROTEIN BROWSER

ECE2-001	ECE2-002	ECE2-003	ECE2-004	ECE2-006	ECE2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECE2-001 ENSP00000384223 ENST00000402825	O60344 [Direct mapping] Endothelin-converting enzyme 2 Methyltransferase-like region Endothelin-converting enzyme 2 region Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008152 [metabolic process] GO:0008168 [methyltransferase activity] GO:0010002 [cardioblast differentiation] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030659 [cytoplasmic vesicle membrane] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	883 aa 99.8 kDa	No	1
ECE2-002 ENSP00000314295 ENST00000324557	O60344 [Direct mapping] Endothelin-converting enzyme 2 Methyltransferase-like region Endothelin-converting enzyme 2 region Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008152 [metabolic process] GO:0008168 [methyltransferase activity] GO:0010002 [cardioblast differentiation] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030659 [cytoplasmic vesicle membrane] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	255 aa 28.3 kDa	No	0
ECE2-003 ENSP00000385846 ENST00000404464	O60344 [Direct mapping] Endothelin-converting enzyme 2 Methyltransferase-like region Endothelin-converting enzyme 2 region Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008168 [methyltransferase activity] GO:0010002 [cardioblast differentiation] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030659 [cytoplasmic vesicle membrane] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	765 aa 86.5 kDa	No	1
ECE2-004 ENSP00000352052 ENST00000359140	O60344 [Direct mapping] Endothelin-converting enzyme 2 Methyltransferase-like region Endothelin-converting enzyme 2 region Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008168 [methyltransferase activity] GO:0010002 [cardioblast differentiation] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030659 [cytoplasmic vesicle membrane] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	736 aa 83.3 kDa	No	1
ECE2-006 ENSP00000350066 ENST00000357474	O60344 [Direct mapping] Endothelin-converting enzyme 2 Methyltransferase-like region Endothelin-converting enzyme 2 region Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0007267 [cell-cell signaling] GO:0007420 [brain development] GO:0007507 [heart development] GO:0008168 [methyltransferase activity] GO:0010002 [cardioblast differentiation] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0030659 [cytoplasmic vesicle membrane] GO:0032259 [methylation] GO:0046872 [metal ion binding] Show all	811 aa 91.2 kDa	No	1
ECE2-007 ENSP00000398444 ENST00000430587	H0Y5G8 [Direct mapping] Endothelin-converting enzyme 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	716 aa 81 kDa	No	1

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The Human Protein Atlas

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