Expression of FIP1L1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

FIP1L1

premium

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FIP1L1
Gene description	Factor interacting with PAPOLA and CPSF1
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA037475
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037475

GENE INFORMATION
Gene name	FIP1L1 (HGNC Symbol)
Synonyms	DKFZp586K0717, FIP1
Description	Factor interacting with PAPOLA and CPSF1 (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Chromosome	4
Cytoband	q12
Chromosome location (bp)	53377643 - 53460861
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145216 (version 83.38)
Entrez gene	81608
UniProt	Q6UN15 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UN15
Antibodypedia	FIP1L1 antibodies

PROTEIN BROWSER

FIP1L1-001	FIP1L1-002	FIP1L1-003	FIP1L1-009	FIP1L1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FIP1L1-001 ENSP00000336752 ENST00000337488	Q6UN15 [Direct mapping] Pre-mRNA 3'-end-processing factor FIP1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005847 [mRNA cleavage and polyadenylation specificity factor complex] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] Show all	594 aa 66.5 kDa	No	0
FIP1L1-002 ENSP00000351383 ENST00000358575	Q6UN15 [Direct mapping] Pre-mRNA 3'-end-processing factor FIP1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] Show all	588 aa 65.7 kDa	No	0
FIP1L1-003 ENSP00000302993 ENST00000306932	Q6UN15 [Direct mapping] Pre-mRNA 3'-end-processing factor FIP1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] Show all	520 aa 58.4 kDa	No	0
FIP1L1-009 ENSP00000425456 ENST00000507922	Q6UN15 [Direct mapping] Pre-mRNA 3'-end-processing factor FIP1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006397 [mRNA processing] GO:0044822 [poly(A) RNA binding] Show all	378 aa 40.8 kDa	No	0
FIP1L1-010 ENSP00000421691 ENST00000504094	H0Y8P7 [Direct mapping] Pre-mRNA 3'-end-processing factor FIP1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		254 aa 29.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.