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CENPC

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GENERAL INFORMATION

Gene name

 CENPC

Gene description

 Centromere protein C

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear bodies (validated)

Additional location

 In addition localized to the Nucleoplasm (validated), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA049740 , HPA058252
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear bodies. In addition localized to the cytosol & nucleoplasm.

Main location

 Nuclear bodies (validated)

Additional location

 Nucleoplasm (validated), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA049740 A-431 Nuclear bodies
HPA049740 MCF7 Nuclear bodies
Cytosol
HPA049740 U-2 OS Nuclear bodies
HPA058252 A-431 Nucleoplasm
Nuclear bodies
HPA058252 RH-30 Nuclear bodies
HPA058252 U-2 OS Nucleoplasm
Nuclear bodies
Cytosol

GENE INFORMATION

Gene name

 CENPC (HGNC Symbol)

Synonyms

 CENP-C, CENPC1, hcp-4, MIF2

Description

 Centromere protein C (HGNC Symbol)

Entrez gene summary

 Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q13.2

Chromosome location (bp)

 67468748 - 67545606

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145241 (version 83.38)

Entrez gene

 1060

UniProt

 Q03188 (UniProt - Evidence at protein level)

neXtProt

 NX_Q03188

Antibodypedia

 CENPC antibodies

PROTEIN BROWSER
CENPC-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPC-001
ENSP00000273853
ENST00000273853
Q03188 [Direct mapping]
Centromere protein C
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000776 [kinetochore]
GO:0000777 [condensed chromosome kinetochore]
GO:0000780 [condensed nuclear chromosome, centromeric region]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005721 [pericentric heterochromatin]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006334 [nucleosome assembly]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0019237 [centromeric DNA binding]
GO:0034080 [CENP-A containing nucleosome assembly]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
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 943 aa
106.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.