Expression of CORIN in cancer - Summary - The Human Protein Atlas

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CORIN

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	CORIN
Gene description	Corin, serine peptidase
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (ASC TERT1)
HPA (normal tissue):	Tissue enhanced (heart muscle)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	CORIN (HGNC Symbol)
Synonyms	ATC2, CRN, Lrp4, PRSC, TMPRSS10
Description	Corin, serine peptidase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type II transmembrane serine protease class of the trypsin superfamily. Members of this family are composed of multiple structurally distinct domains. The encoded protein converts pro-atrial natriuretic peptide to biologically active atrial natriuretic peptide, a cardiac hormone that regulates blood volume and pressure. This protein may also function as a pro-brain-type natriuretic peptide convertase. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Chromosome	4
Cytoband	p12
Chromosome location (bp)	47593998 - 47838106
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145244 (version 83.38)
Entrez gene	10699
UniProt	Q9Y5Q5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5Q5
Antibodypedia	CORIN antibodies

PROTEIN BROWSER

CORIN-001	CORIN-003	CORIN-005	CORIN-009	CORIN-010	CORIN-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CORIN-001 ENSP00000273857 ENST00000273857	Q9Y5Q5 [Direct mapping] Atrial natriuretic peptide-converting enzyme Atrial natriuretic peptide-converting enzyme, N-terminal propeptide Atrial natriuretic peptide-converting enzyme, activated protease fragment Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment Show all	Enzymes Peptidases Serine-type peptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003050 [regulation of systemic arterial blood pressure by atrial natriuretic peptide] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006508 [proteolysis] GO:0007565 [female pregnancy] GO:0008217 [regulation of blood pressure] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] GO:0035813 [regulation of renal sodium excretion] Show all	1042 aa 116.5 kDa	No	1
CORIN-003 ENSP00000425401 ENST00000505909	J3KR90 [Direct mapping] Atrial natriuretic peptide-converting enzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] Show all	1005 aa 112.4 kDa	No	1
CORIN-005 ENSP00000424212 ENST00000502252	J3KR88 [Direct mapping] Atrial natriuretic peptide-converting enzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016486 [peptide hormone processing] Show all	975 aa 109.2 kDa	No	1
CORIN-009 ENSP00000425597 ENST00000508498	E7EQE7 [Direct mapping] Atrial natriuretic peptide-converting enzyme Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016486 [peptide hormone processing] Show all	903 aa 101.5 kDa	No	0
CORIN-010 ENSP00000423216 ENST00000504584	J3KR83 [Direct mapping] Atrial natriuretic peptide-converting enzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] Show all	734 aa 81.8 kDa	No	1
CORIN-201 ENSP00000484087 ENST00000610355	A0A087X1D5 [Direct mapping] Atrial natriuretic peptide-converting enzyme Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	938 aa 105.1 kDa	No	1

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The Human Protein Atlas

The Human Protein Atlas project is funded
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