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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ATP10D
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ATP10D

Gene description

ATPase, class V, type 10D

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA050808
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA050808

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues showed weak to moderate cytoplasmic staining. Several cases of low grade non-Hodgkins lymphomas displayed strong cytoplasmic and nuclear staining. Red blood cells were distinctly stained. Malignant gliomas and skin cancers were negative.

GENE INFORMATION

Gene name

ATP10D (HGNC Symbol)

Synonyms

ATPVD, KIAA1487

Description

ATPase, class V, type 10D (HGNC Symbol)

Entrez gene summary

Chromosome

4

Cytoband

p12

Chromosome location (bp)

47485288 - 47593486

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145246 (version 83.38)

Entrez gene

57205

UniProt

Q9P241 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9P241

Antibodypedia

ATP10D antibodies

PROTEIN BROWSER

ATP10D-001
ATP10D-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ATP10D-001
ENSP00000273859
ENST00000273859
Q9P241 [Direct mapping]
Probable phospholipid-transporting ATPase VD
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005654 [nucleoplasm]
GO:0005783 [endoplasmic reticulum]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005886 [plasma membrane]
GO:0006812 [cation transport]
GO:0006886 [intracellular protein transport]
GO:0008152 [metabolic process]
GO:0015914 [phospholipid transport]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
Show all
1426 aa
160.3 kDa
No >9
ATP10D-002
ENSP00000420909
ENST00000504445
Q6PEW3 [Direct mapping]
ATP10D protein; Probable phospholipid-transporting ATPase VD
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Show all
GO:0000166 [nucleotide binding]
GO:0000287 [magnesium ion binding]
GO:0004012 [phospholipid-translocating ATPase activity]
GO:0005524 [ATP binding]
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0016021 [integral component of membrane]
GO:0045332 [phospholipid translocation]
GO:0046872 [metal ion binding]
Show all
535 aa
61 kDa
No 5

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