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ENOPH1

GENERAL INFORMATION

Gene name

 ENOPH1

Gene description

 Enolase-phosphatase 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA044607 , CAB004985
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Melanoma

STAINING SUMMARY
HPA044607
CAB004985

GENE INFORMATION

Gene name

 ENOPH1 (HGNC Symbol)

Synonyms

 E1, MASA, mtnC

Description

 Enolase-phosphatase 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q21.22

Chromosome location (bp)

 82430562 - 82461091

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145293 (version 83.38)

Entrez gene

 58478

UniProt

 Q9UHY7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UHY7

Antibodypedia

 ENOPH1 antibodies

PROTEIN BROWSER
ENOPH1-001
ENOPH1-002
ENOPH1-003
ENOPH1-201
ENOPH1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENOPH1-001
ENSP00000273920
ENST00000273920
Q9UHY7 [Direct mapping]
Enolase-phosphatase E1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000096 [sulfur amino acid metabolic process]
GO:0000287 [magnesium ion binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006595 [polyamine metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0019509 [L-methionine biosynthetic process from methylthioadenosine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043874 [acireductone synthase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 261 aa
28.9 kDa 		No 0
ENOPH1-002
ENSP00000422005
ENST00000509635
D6RA00 [Direct mapping]
Enolase-phosphatase E1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0019509 [L-methionine biosynthetic process from methylthioadenosine]
GO:0043874 [acireductone synthase activity]
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 173 aa
19.2 kDa 		No 0
ENOPH1-003
ENSP00000427209
ENST00000505846
Q9UHY7 [Direct mapping]
Enolase-phosphatase E1
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000096 [sulfur amino acid metabolic process]
GO:0000287 [magnesium ion binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006595 [polyamine metabolic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0019509 [L-methionine biosynthetic process from methylthioadenosine]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0043874 [acireductone synthase activity]
GO:0044281 [small molecule metabolic process]
GO:0070062 [extracellular exosome]
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 115 aa
12.6 kDa 		No 0
ENOPH1-201
ENSP00000483615
ENST00000610545
A0A0C4DGY8 [Direct mapping]
Enolase-phosphatase E1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0016787 [hydrolase activity]
GO:0019509 [L-methionine biosynthetic process from methylthioadenosine]
GO:0043874 [acireductone synthase activity]
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 149 aa
16.5 kDa 		No 0
ENOPH1-202
ENSP00000477863
ENST00000618400
A0A087WTH0 [Direct mapping]
Enolase-phosphatase E1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0019509 [L-methionine biosynthetic process from methylthioadenosine]
GO:0043874 [acireductone synthase activity]
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 207 aa
23.4 kDa 		No 0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.