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Cancer

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CAMK2D
  • TISSUE

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  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CAMK2D

Gene description

Calcium/calmodulin-dependent protein kinase II delta

Protein class

Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

12
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression at variable levels in selected tissues, most abundant in heart muscle.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

Approved based on 4 antibodies.
HPA026281 , HPA051783 , HPA051785 , HPA053973
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

CAMK2D (HGNC Symbol)

Synonyms

CAMKD

Description

Calcium/calmodulin-dependent protein kinase II delta (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the serine/threonine protein kinase family and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. In mammalian cells, the enzyme is composed of four different chains: alpha, beta, gamma, and delta. The product of this gene is a delta chain. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Distinct isoforms of this chain have different expression patterns.[provided by RefSeq, Nov 2008]

Chromosome

4

Cytoband

q26

Chromosome location (bp)

113451032 - 113761927

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145349 (version 83.38)

Entrez gene

817

UniProt

Q13557 (UniProt - Evidence at protein level)

neXtProt

NX_Q13557

Antibodypedia

CAMK2D antibodies

PROTEIN BROWSER

«
CAMK2D-001
CAMK2D-002
CAMK2D-003
CAMK2D-004
CAMK2D-005
CAMK2D-006
CAMK2D-008
CAMK2D-009
CAMK2D-012
CAMK2D-013
CAMK2D-016
CAMK2D-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CAMK2D-001
ENSP00000378032
ENST00000394524
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
478 aa
54.1 kDa
No 1
CAMK2D-002
ENSP00000369098
ENST00000379773
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
478 aa
54.1 kDa
No 1
CAMK2D-003
ENSP00000339740
ENST00000342666
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
A0A024RDK3 [Target identity:100%; Query identity:100%]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0001666 [response to hypoxia]
GO:0002026 [regulation of the force of heart contraction]
GO:0002028 [regulation of sodium ion transport]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0006816 [calcium ion transport]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010389 [regulation of G2/M transition of mitotic cell cycle]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0014704 [intercalated disc]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016020 [membrane]
GO:0016529 [sarcoplasmic reticulum]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030007 [cellular potassium ion homeostasis]
GO:0030315 [T-tubule]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0031594 [neuromuscular junction]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0035022 [positive regulation of Rac protein signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0043025 [neuronal cell body]
GO:0043194 [axon initial segment]
GO:0043234 [protein complex]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0050998 [nitric-oxide synthase binding]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060048 [cardiac muscle contraction]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0061049 [cell growth involved in cardiac muscle cell development]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
499 aa
56.4 kDa
No 1
CAMK2D-004
ENSP00000378030
ENST00000394522
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
492 aa
55.7 kDa
No 1
CAMK2D-005
ENSP00000424245
ENST00000505990
E9PBG7 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
512 aa
57.8 kDa
No 1
CAMK2D-006
ENSP00000422566
ENST00000508738
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
489 aa
55.4 kDa
No 1
CAMK2D-008
ENSP00000425824
ENST00000511664
E9PF82 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
533 aa
60 kDa
No 1
CAMK2D-009
ENSP00000423482
ENST00000515496
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
510 aa
57.6 kDa
No 1
CAMK2D-012
ENSP00000423677
ENST00000514328
D6R938 [Direct mapping]
Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta, isoform CRA_e; Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
498 aa
56.3 kDa
No 1
CAMK2D-013
ENSP00000424247
ENST00000513132
H0Y9J2 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0006468 [protein phosphorylation]
Show all
182 aa
20.4 kDa
Yes 0
CAMK2D-016
ENSP00000423753
ENST00000509594
H0Y9C2 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
Show all
194 aa
22.1 kDa
No 0
CAMK2D-201
ENSP00000296402
ENST00000296402
Q13557 [Direct mapping]
Calcium/calmodulin-dependent protein kinase type II subunit delta
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CAMK Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0001558 [regulation of cell growth]
GO:0002026 [regulation of the force of heart contraction]
GO:0003254 [regulation of membrane depolarization]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004683 [calmodulin-dependent protein kinase activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007268 [synaptic transmission]
GO:0007411 [axon guidance]
GO:0008016 [regulation of heart contraction]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0010613 [positive regulation of cardiac muscle hypertrophy]
GO:0010649 [regulation of cell communication by electrical coupling]
GO:0010666 [positive regulation of cardiac muscle cell apoptotic process]
GO:0010880 [regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum]
GO:0010881 [regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion]
GO:0016020 [membrane]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019871 [sodium channel inhibitor activity]
GO:0030666 [endocytic vesicle membrane]
GO:0031432 [titin binding]
GO:0032469 [endoplasmic reticulum calcium ion homeostasis]
GO:0033017 [sarcoplasmic reticulum membrane]
GO:0034605 [cellular response to heat]
GO:0034704 [calcium channel complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042383 [sarcolemma]
GO:0042803 [protein homodimerization activity]
GO:0044325 [ion channel binding]
GO:0045087 [innate immune response]
GO:0046777 [protein autophosphorylation]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051259 [protein oligomerization]
GO:0055119 [relaxation of cardiac muscle]
GO:0060314 [regulation of ryanodine-sensitive calcium-release channel activity]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060341 [regulation of cellular localization]
GO:0071277 [cellular response to calcium ion]
GO:0086003 [cardiac muscle cell contraction]
GO:0086091 [regulation of heart rate by cardiac conduction]
GO:0098901 [regulation of cardiac muscle cell action potential]
GO:0098909 [regulation of cardiac muscle cell action potential involved in regulation of contraction]
GO:1900034 [regulation of cellular response to heat]
GO:1901725 [regulation of histone deacetylase activity]
GO:1901844 [regulation of cell communication by electrical coupling involved in cardiac conduction]
GO:1901897 [regulation of relaxation of cardiac muscle]
GO:1902306 [negative regulation of sodium ion transmembrane transport]
GO:1902514 [regulation of generation of L-type calcium current]
GO:2000650 [negative regulation of sodium ion transmembrane transporter activity]
Show all
478 aa
54.1 kDa
No 1

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