Expression of TIFA in cancer - Summary - The Human Protein Atlas

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TIFA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TIFA
Gene description	TRAF-interacting protein with forkhead-associated domain
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA045889
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045889

GENE INFORMATION
Gene name	TIFA (HGNC Symbol)
Synonyms	MGC20791, T2BP, T6BP, TIFAA
Description	TRAF-interacting protein with forkhead-associated domain (HGNC Symbol)
Entrez gene summary
Chromosome	4
Cytoband	q25
Chromosome location (bp)	112274542 - 112285903
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145365 (version 83.38)
Entrez gene	92610
UniProt	Q96CG3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96CG3
Antibodypedia	TIFA antibodies

PROTEIN BROWSER

TIFA-001	TIFA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIFA-001 ENSP00000354911 ENST00000361717	Q96CG3 [Direct mapping] TRAF-interacting protein with FHA domain-containing protein A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] Show all	184 aa 21.4 kDa	No	0
TIFA-002 ENSP00000424231 ENST00000500655	Q96CG3 [Direct mapping] TRAF-interacting protein with FHA domain-containing protein A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	184 aa 21.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.