Expression of FABP2 in cancer - Summary - The Human Protein Atlas

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FABP2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	FABP2
Gene description	Fatty acid binding protein 2, intestinal
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Group enriched (duodenum, small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in the small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA034607 , CAB047325
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer, stomach cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034607	CAB047325

GENE INFORMATION
Gene name	FABP2 (HGNC Symbol)
Synonyms	I-FABP
Description	Fatty acid binding protein 2, intestinal (HGNC Symbol)
Entrez gene summary	The intracellular fatty acid-binding proteins (FABPs) belong to a multigene family with nearly twenty identified members. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. This gene has a polymorphism at codon 54 that identified an alanine-encoding allele and a threonine-encoding allele. Thr-54 protein is associated with increased fat oxidation and insulin resistance. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	q26
Chromosome location (bp)	119317250 - 119322390
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145384 (version 83.38)
Entrez gene	2169
UniProt	P12104 (UniProt - Evidence at protein level)
neXtProt	NX_P12104
Antibodypedia	FABP2 antibodies

PROTEIN BROWSER

FABP2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FABP2-001 ENSP00000274024 ENST00000274024	P12104 [Direct mapping] Fatty acid-binding protein, intestinal Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005504 [fatty acid binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005829 [cytosol] GO:0006810 [transport] GO:0007586 [digestion] GO:0008289 [lipid binding] GO:0019433 [triglyceride catabolic process] GO:0044281 [small molecule metabolic process] Show all	132 aa 15.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.