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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CCNA2
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CCNA2

Gene description

Cyclin A2

Protein class

Cancer-related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in a varying fraction of cells in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending reevalution.

Reliability score

Approved based on 2 antibodies.
HPA020626 , CAB000114
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PROGNOSTIC SUMMARY

Prognostic marker in renal cancer (unfavourable), pancreatic cancer (unfavourable), liver cancer (unfavourable), lung cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Pancreatic cancer p<0.001
Liver cancer p<0.001
Lung cancer p<0.001
Endometrial cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Carcinoid

STAINING SUMMARY

HPA020626
CAB000114

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Weak to moderate cytoplasmic and nuclear immunoreactivity was displayed in lymphomas, colorectal, cervical, endometrial and urothelial cancers. The remaining cancers were generally negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Most cancer tissues showed moderate to strong nuclear positivity in varying fractions of cells.

GENE INFORMATION

Gene name

CCNA2 (HGNC Symbol)

Synonyms

CCN1, CCNA

Description

Cyclin A2 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]

Chromosome

4

Cytoband

q27

Chromosome location (bp)

121816444 - 121823933

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000145386 (version 83.38)

Entrez gene

890

UniProt

P20248 (UniProt - Evidence at protein level)

neXtProt

NX_P20248

Antibodypedia

CCNA2 antibodies

PROTEIN BROWSER

CCNA2-001
CCNA2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCNA2-001
ENSP00000274026
ENST00000274026
P20248 [Direct mapping]
Cyclin-A2
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   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001939 [female pronucleus]
GO:0001940 [male pronucleus]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0019901 [protein kinase binding]
GO:0031100 [organ regeneration]
GO:0032355 [response to estradiol]
GO:0033762 [response to glucagon]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0044320 [cellular response to leptin stimulus]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048146 [positive regulation of fibroblast proliferation]
GO:0051301 [cell division]
GO:0071314 [cellular response to cocaine]
GO:0071373 [cellular response to luteinizing hormone stimulus]
GO:0071392 [cellular response to estradiol stimulus]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071456 [cellular response to hypoxia]
GO:0071732 [cellular response to nitric oxide]
GO:0090102 [cochlea development]
GO:1990314 [cellular response to insulin-like growth factor stimulus]
Show all
432 aa
48.6 kDa
No 0
CCNA2-201
ENSP00000481380
ENST00000618014
P20248 [Direct mapping]
Cyclin-A2
Show all
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0007067 [mitotic nuclear division]
GO:0007095 [mitotic G2 DNA damage checkpoint]
GO:0007265 [Ras protein signal transduction]
GO:0016032 [viral process]
GO:0051301 [cell division]
Show all
432 aa
48.6 kDa
No 0

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