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Weak to moderate cytoplasmic and nuclear immunoreactivity was displayed in lymphomas, colorectal, cervical, endometrial and urothelial cancers. The remaining cancers were generally negative.
Most cancer tissues showed moderate to strong nuclear positivity in varying fractions of cells.
GENE INFORMATION
Gene name
CCNA2 (HGNC Symbol)
Synonyms
CCN1, CCNA
Description
Cyclin A2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq, Jul 2008]