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Cancer tissues showed moderate cytoplasmic and occasional nuclear staining. Hepatocellular carcinomas, several testicular cancers and a few cases of endometrial and stomach cancers displayed strong positivity. Urothelial cancers showed moderate to strong cytoplasmic and nuclear staining.
GENE INFORMATION
Gene name
RPS3A (HGNC Symbol)
Synonyms
MFTL, S3A
Description
Ribosomal protein S3A (HGNC Symbol)
Entrez gene summary
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S3AE family of ribosomal proteins. It is located in the cytoplasm. Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos-transformed rat cells results in reversion of the transformed phenotype. This gene is co-transcribed with the U73A and U73B small nucleolar RNA genes, which are located in its fourth and third introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]