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A few cases of renal, testicular and endometrial cancers displayed weak to moderate cytoplasmic and nuclear staining. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
PDGFC (HGNC Symbol)
Synonyms
fallotein, SCDGF
Description
Platelet derived growth factor C (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Q9NRA1 [Direct mapping] Platelet-derived growth factor C Platelet-derived growth factor C, latent form Platelet-derived growth factor C, receptor-binding form
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)