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CBR4

GENERAL INFORMATION

Gene name

 CBR4

Gene description

 Carbonyl reductase 4

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA037499
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037499

GENE INFORMATION

Gene name

 CBR4 (HGNC Symbol)

Synonyms

 FLJ14431, SDR45C1

Description

 Carbonyl reductase 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 4

Cytoband

 q32.3

Chromosome location (bp)

 168863770 - 169010275

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145439 (version 83.38)

Entrez gene

 84869

UniProt

 Q8N4T8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N4T8

Antibodypedia

 CBR4 antibodies

PROTEIN BROWSER
CBR4-001
CBR4-002
CBR4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CBR4-001
ENSP00000303525
ENST00000306193
Q8N4T8 [Direct mapping]
Carbonyl reductase family member 4
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003955 [NAD(P)H dehydrogenase (quinone) activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006633 [fatty acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008753 [NADPH dehydrogenase (quinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0048038 [quinone binding]
GO:0051289 [protein homotetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
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 237 aa
25.3 kDa 		No 0
CBR4-002
ENSP00000427615
ENST00000504480
Q8N4T8 [Direct mapping]
Carbonyl reductase family member 4
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003955 [NAD(P)H dehydrogenase (quinone) activity]
GO:0005515 [protein binding]
GO:0005759 [mitochondrial matrix]
GO:0006633 [fatty acid biosynthetic process]
GO:0008152 [metabolic process]
GO:0008753 [NADPH dehydrogenase (quinone) activity]
GO:0016491 [oxidoreductase activity]
GO:0044597 [daunorubicin metabolic process]
GO:0044598 [doxorubicin metabolic process]
GO:0048038 [quinone binding]
GO:0051289 [protein homotetramerization]
GO:0055114 [oxidation-reduction process]
GO:0070402 [NADPH binding]
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 179 aa
18.8 kDa 		No 0
CBR4-006
ENSP00000423128
ENST00000504561
H0Y962 [Direct mapping]
Carbonyl reductase family member 4
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0055114 [oxidation-reduction process]
Show all
 186 aa
19.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.