Expression of MARCH6 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

MARCH6

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MARCH6
Gene description	Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues, most abundantly in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA063246
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063246

GENE INFORMATION
Gene name	MARCH6 (HGNC Symbol)
Synonyms	MARCH-VI, RNF176, TEB4
Description	Membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (HGNC Symbol)
Entrez gene summary	This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	5
Cytoband	p15.2
Chromosome location (bp)	10353703 - 10440388
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145495 (version 83.38)
Entrez gene	10299
UniProt	O60337 (UniProt - Evidence at protein level)
neXtProt	NX_O60337
Antibodypedia	MARCH6 antibodies

PROTEIN BROWSER

MARCH6-001	MARCH6-004	MARCH6-005	MARCH6-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCH6-001 ENSP00000274140 ENST00000274140	O60337 [Direct mapping] E3 ubiquitin-protein ligase MARCH6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000835 [ER ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0008270 [zinc ion binding] GO:0010498 [proteasomal protein catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0036503 [ERAD pathway] GO:0070936 [protein K48-linked ubiquitination] GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway] GO:1990381 [ubiquitin-specific protease binding] Show all	910 aa 102.5 kDa	No	>9
MARCH6-004 ENSP00000425930 ENST00000503788	O60337 [Direct mapping] E3 ubiquitin-protein ligase MARCH6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000835 [ER ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0008270 [zinc ion binding] GO:0010498 [proteasomal protein catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0036503 [ERAD pathway] GO:0070936 [protein K48-linked ubiquitination] GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway] GO:1990381 [ubiquitin-specific protease binding] Show all	805 aa 90.4 kDa	No	>9
MARCH6-005 ENSP00000414643 ENST00000449913	O60337 [Direct mapping] E3 ubiquitin-protein ligase MARCH6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000835 [ER ubiquitin ligase complex] GO:0004842 [ubiquitin-protein transferase activity] GO:0008270 [zinc ion binding] GO:0010498 [proteasomal protein catabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016874 [ligase activity] GO:0019899 [enzyme binding] GO:0030176 [integral component of endoplasmic reticulum membrane] GO:0031624 [ubiquitin conjugating enzyme binding] GO:0036503 [ERAD pathway] GO:0070936 [protein K48-linked ubiquitination] GO:1904264 [ubiquitin protein ligase activity involved in ERAD pathway] GO:1990381 [ubiquitin-specific protease binding] Show all	862 aa 97.2 kDa	No	>9
MARCH6-006 ENSP00000424512 ENST00000510792	A0A0B4J206 [Direct mapping] E3 ubiquitin-protein ligase MARCH6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	608 aa 69.2 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.