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Most cancers displayed moderate to strong cytoplasmic immunoreactivity with a granular pattern. Lymphomas and testicular cancers along with most gliomas, squamous and basal cell carcinomas were negative.
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]