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MYO10

GENERAL INFORMATION

Gene name

 MYO10

Gene description

 Myosin X

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-MEL-30)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression at variable levels. Highest levels in gastrointestinal tract, CNS and genitalia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA024223 , CAB015224
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and cervical cancer (unfavourable).
Renal cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA024223
CAB015224

GENE INFORMATION

Gene name

 MYO10 (HGNC Symbol)

Synonyms

 KIAA0799

Description

 Myosin X (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the myosin superfamily. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-10 (MYH10). Unconventional myosins contain the basic domains of conventional myosins and are further distinguished from class members by their tail domains. This gene functions as an actin-based molecular motor and plays a role in integration of F-actin and microtubule cytoskeletons during meiosis. [provided by RefSeq, Dec 2011]

Chromosome

 5

Cytoband

 p15.1

Chromosome location (bp)

 16661914 - 16936276

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145555 (version 83.38)

Entrez gene

 4651

UniProt

 Q9HD67 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HD67

Antibodypedia

 MYO10 antibodies

PROTEIN BROWSER
MYO10-001
MYO10-002
MYO10-003
MYO10-004
MYO10-005
MYO10-006
MYO10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MYO10-001
ENSP00000421280
ENST00000513610
Q9HD67 [Direct mapping]
Unconventional myosin-X
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0008360 [regulation of cell shape]
GO:0016459 [myosin complex]
GO:0022409 [positive regulation of cell-cell adhesion]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030507 [spectrin binding]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0030898 [actin-dependent ATPase activity]
GO:0031527 [filopodium membrane]
GO:0032433 [filopodium tip]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051489 [regulation of filopodium assembly]
GO:0060002 [plus-end directed microfilament motor activity]
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 2058 aa
237.3 kDa 		No 0
MYO10-002
ENSP00000426664
ENST00000507288
Q9HD67 [Direct mapping]
Unconventional myosin-X
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001726 [ruffle]
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005547 [phosphatidylinositol-3,4,5-trisphosphate binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007411 [axon guidance]
GO:0008152 [metabolic process]
GO:0008360 [regulation of cell shape]
GO:0016459 [myosin complex]
GO:0030027 [lamellipodium]
GO:0030507 [spectrin binding]
GO:0030705 [cytoskeleton-dependent intracellular transport]
GO:0030898 [actin-dependent ATPase activity]
GO:0031527 [filopodium membrane]
GO:0032433 [filopodium tip]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0045087 [innate immune response]
GO:0051015 [actin filament binding]
GO:0051489 [regulation of filopodium assembly]
GO:0060002 [plus-end directed microfilament motor activity]
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 97 aa
11.2 kDa 		No 0
MYO10-003
ENSP00000426783
ENST00000502436
E9PCN3 [Direct mapping]
Unconventional myosin-X
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003774 [motor activity]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 212 aa
24 kDa 		No 0
MYO10-004
ENSP00000421309
ENST00000513882
D6RGD1 [Direct mapping]
Unconventional myosin-X
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 830 aa
96.1 kDa 		No 0
MYO10-005
ENSP00000421170
ENST00000505695
E9PEW5 [Direct mapping]
Unconventional myosin-X
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
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 1397 aa
161.5 kDa 		No 0
MYO10-006
ENSP00000425051
ENST00000515803
E9PEW5 [Direct mapping]
Unconventional myosin-X
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 1397 aa
161.5 kDa 		No 0
MYO10-201
ENSP00000274203
ENST00000274203
A0A0A0MQX1 [Direct mapping]
Unconventional myosin-X
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003774 [motor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005856 [cytoskeleton]
GO:0007165 [signal transduction]
GO:0008152 [metabolic process]
GO:0016459 [myosin complex]
Show all
 2069 aa
238.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.