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SKP2

GENERAL INFORMATION

Gene name

 SKP2

Gene description

 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (placenta)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in placenta.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 3 antibodies.
HPA054633 , CAB013491 , CAB013533
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), melanoma (unfavourable) and ovarian cancer (favourable).
Renal cancer p<0.001
Melanoma p<0.001
Ovarian cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA054633
CAB013491
CAB013533

GENE INFORMATION

Gene name

 SKP2 (HGNC Symbol)

Synonyms

 FBL1, FBXL1, p45

Description

 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]

Chromosome

 5

Cytoband

 p13.2

Chromosome location (bp)

 36151989 - 36184319

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000145604 (version 83.38)

Entrez gene

 6502

UniProt

 Q13309 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13309

Antibodypedia

 SKP2 antibodies

PROTEIN BROWSER
SKP2-001
SKP2-002
SKP2-006
SKP2-007
SKP2-201
SKP2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SKP2-001
ENSP00000274254
ENST00000274254
Q13309 [Direct mapping]
S-phase kinase-associated protein 2
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   Phobius predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008283 [cell proliferation]
GO:0016235 [aggresome]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0061630 [ubiquitin protein ligase activity]
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 410 aa
46.6 kDa 		No 0
SKP2-002
ENSP00000274255
ENST00000274255
Q13309 [Direct mapping]
S-phase kinase-associated protein 2
A0A024R069 [Target identity:100%; Query identity:100%]
S-phase kinase-associated protein 2 (P45), isoform CRA_c
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000209 [protein polyubiquitination]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006511 [ubiquitin-dependent protein catabolic process]
GO:0008283 [cell proliferation]
GO:0016235 [aggresome]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0033148 [positive regulation of intracellular estrogen receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0048661 [positive regulation of smooth muscle cell proliferation]
GO:0051726 [regulation of cell cycle]
GO:0061630 [ubiquitin protein ligase activity]
GO:0071460 [cellular response to cell-matrix adhesion]
GO:1902916 [positive regulation of protein polyubiquitination]
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 424 aa
47.8 kDa 		No 0
SKP2-006
ENSP00000421941
ENST00000508514
D6RAG5 [Direct mapping]
S-phase kinase-associated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0016235 [aggresome]
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 217 aa
24.7 kDa 		No 0
SKP2-007
ENSP00000423188
ENST00000513151
D6R9R7 [Direct mapping]
S-phase kinase-associated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 255 aa
28.6 kDa 		No 0
SKP2-201
ENSP00000443492
ENST00000546211
A0A0A0MTL5 [Direct mapping]
S-phase kinase-associated protein 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 435 aa
48.9 kDa 		No 0
SKP2-202
ENSP00000478031
ENST00000620197
Q13309 [Direct mapping]
S-phase kinase-associated protein 2
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0008283 [cell proliferation]
GO:0016235 [aggresome]
GO:0016567 [protein ubiquitination]
GO:0019005 [SCF ubiquitin ligase complex]
GO:0031145 [anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0031146 [SCF-dependent proteasomal ubiquitin-dependent protein catabolic process]
GO:0042802 [identical protein binding]
GO:0042981 [regulation of apoptotic process]
GO:0061630 [ubiquitin protein ligase activity]
Show all
 210 aa
23.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.