Cell atlas - OSMR - The Human Protein Atlas

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OSMR

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	OSMR
Gene description	Oncostatin M receptor
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA017278
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA017278	A-431	Nucleoli
	HPA017278	U-2 OS	Nucleoli
	HPA017278	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	OSMR (HGNC Symbol)
Synonyms	OSMRB
Description	Oncostatin M receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Chromosome	5
Cytoband	p13.1
Chromosome location (bp)	38845858 - 38945596
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145623 (version 83.38)
Entrez gene	9180
UniProt	Q99650 (UniProt - Evidence at protein level)
neXtProt	NX_Q99650
Antibodypedia	OSMR antibodies

PROTEIN BROWSER

OSMR-001	OSMR-003	OSMR-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSMR-001 ENSP00000274276 ENST00000274276	Q99650 [Direct mapping] Oncostatin-M-specific receptor subunit beta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002675 [positive regulation of acute inflammatory response] GO:0004896 [cytokine receptor activity] GO:0004924 [oncostatin-M receptor activity] GO:0005515 [protein binding] GO:0005900 [oncostatin-M receptor complex] GO:0008284 [positive regulation of cell proliferation] GO:0009897 [external side of plasma membrane] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019838 [growth factor binding] GO:0019955 [cytokine binding] GO:0034097 [response to cytokine] GO:0038165 [oncostatin-M-mediated signaling pathway] Show all	979 aa 110.5 kDa	Yes	1
OSMR-003 ENSP00000422023 ENST00000502536	Q99650 [Direct mapping] Oncostatin-M-specific receptor subunit beta Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002675 [positive regulation of acute inflammatory response] GO:0004924 [oncostatin-M receptor activity] GO:0005515 [protein binding] GO:0005900 [oncostatin-M receptor complex] GO:0008284 [positive regulation of cell proliferation] GO:0016324 [apical plasma membrane] GO:0019838 [growth factor binding] GO:0034097 [response to cytokine] GO:0038165 [oncostatin-M-mediated signaling pathway] Show all	342 aa 39.5 kDa	Yes	0
OSMR-004 ENSP00000423913 ENST00000513831	H0Y9E3 [Direct mapping] Oncostatin-M-specific receptor subunit beta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	188 aa 20.5 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.