Expression of PPIP5K2 in cancer - Summary - The Human Protein Atlas

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PPIP5K2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPIP5K2
Gene description	Diphosphoinositol pentakisphosphate kinase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissue types.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA037895 , HPA038442
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA037895	HPA038442

GENE INFORMATION
Gene name	PPIP5K2 (HGNC Symbol)
Synonyms	CFAP160, HISPPD1, KIAA0433, VIP2
Description	Diphosphoinositol pentakisphosphate kinase 2 (HGNC Symbol)
Entrez gene summary	Inositol phosphates (IPs) and diphosphoinositol phosphates (PP-IPs), also known as inositol pyrophosphates, act as cell signaling molecules. HISPPD1 has both IP6 kinase (EC 2.7.4.21) and PP-IP5 (also called IP7) kinase (EC 2.7.4.24) activities that produce the high-energy pyrophosphates PP-IP5 and PP2-IP4 (also called IP8), respectively (Fridy et al., 2007 [PubMed 17690096]).[supplied by OMIM, Mar 2008]
Chromosome	5
Cytoband	q21.1
Chromosome location (bp)	103120149 - 103212799
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000145725 (version 83.38)
Entrez gene	23262
UniProt	O43314 (UniProt - Evidence at protein level)
neXtProt	NX_O43314
Antibodypedia	PPIP5K2 antibodies

PROTEIN BROWSER

PPIP5K2-001	PPIP5K2-002	PPIP5K2-003	PPIP5K2-004	PPIP5K2-005	PPIP5K2-006	PPIP5K2-008	PPIP5K2-009	PPIP5K2-014	PPIP5K2-016	PPIP5K2-201	PPIP5K2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPIP5K2-001 ENSP00000313070 ENST00000321521	O43314 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity] GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0003993 [acid phosphatase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006020 [inositol metabolic process] GO:0016310 [phosphorylation] GO:0016311 [dephosphorylation] GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	1222 aa 138.1 kDa	No	0
PPIP5K2-002 ENSP00000482907 ENST00000613674	A0A087WZV0 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	1278 aa 144.4 kDa	No	0
PPIP5K2-003 ENSP00000351126 ENST00000358359	O43314 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity] GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0003993 [acid phosphatase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006020 [inositol metabolic process] GO:0016310 [phosphorylation] GO:0016311 [dephosphorylation] GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	1243 aa 140.4 kDa	No	0
PPIP5K2-004 ENSP00000424948 ENST00000509597	H0Y9S9 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	398 aa 45 kDa	No	0
PPIP5K2-005 ENSP00000422525 ENST00000507921	D6RBU4 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	452 aa 51.2 kDa	No	0
PPIP5K2-006 ENSP00000421513 ENST00000515845	D6RFG4 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.7 kDa	No	0
PPIP5K2-008 ENSP00000467529 ENST00000502481	K7EPT7 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.8 kDa	No	0
PPIP5K2-009 ENSP00000424535 ENST00000507310	H0Y9M0 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		209 aa 24 kDa	No	0
PPIP5K2-014 ENSP00000467099 ENST00000511022	K7ENU7 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		255 aa 27.7 kDa	No	0
PPIP5K2-016 ENSP00000480381 ENST00000613907	A0A087WWN8 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	357 aa 39.7 kDa	No	0
PPIP5K2-201 ENSP00000416016 ENST00000414217	O43314 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000827 [inositol-1,3,4,5,6-pentakisphosphate kinase activity] GO:0000832 [inositol hexakisphosphate 5-kinase activity] GO:0003993 [acid phosphatase activity] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006020 [inositol metabolic process] GO:0016310 [phosphorylation] GO:0016311 [dephosphorylation] GO:0033857 [diphosphoinositol-pentakisphosphate kinase activity] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0052723 [inositol hexakisphosphate 1-kinase activity] GO:0052724 [inositol hexakisphosphate 3-kinase activity] Show all	1222 aa 138.1 kDa	No	0
PPIP5K2-202 ENSP00000486357 ENST00000627916	A0A087WZV0 [Direct mapping] Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	1278 aa 144.4 kDa	No	0

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