Expression of ADAMTS19 in cancer - Summary - The Human Protein Atlas

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ADAMTS19

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ADAMTS19
Gene description	ADAM metallopeptidase with thrombospondin type 1 motif, 19
Protein class	Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (endometrial cancer)
HPA (cell line):	Group enriched (MCF7, SH-SY5Y)
HPA (normal tissue):	Group enriched (cervix, uterine, endometrium, placenta, smooth muscle)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA056171
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (endometrial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056171

GENE INFORMATION
Gene name	ADAMTS19
Synonyms
Description	ADAM metallopeptidase with thrombospondin type 1 motif, 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has high sequence similarity to the protein encoded by ADAMTS16, another family member. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q23.3
Chromosome location (bp)	129460265 - 129738683
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000145808 (version 83.38)
Entrez gene	171019
UniProt	Q8TE59 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TE59
Antibodypedia	ADAMTS19 antibodies

PROTEIN BROWSER

ADAMTS19-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAMTS19-001 ENSP00000274487 ENST00000274487	Q8TE59 [Direct mapping] A disintegrin and metalloproteinase with thrombospondin motifs 19 Show all	Enzymes Peptidases Metallopeptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0004222 [metalloendopeptidase activity] GO:0005578 [proteinaceous extracellular matrix] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008270 [zinc ion binding] GO:0031012 [extracellular matrix] Show all	1207 aa 134 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.